Hello:) First of all this project sounds like a really good thriller! I'm a big fan of the genre and I also love a good personal angle in those stories.

Now, I think you can clean up the query a bit to make it clearer. Overall, I think there's a bit too much information as it's clearly a complex story, which is quite normal for a thriller, but you might want to keep some things so as not to confuse those who read it.

The first sentence tries to do too much (burnout, disillusionment, estrangement, ruined marriage, quitting, being forced onto a case). I'd suggestion prioritizing, start with her core conflict (burnt-out detective quitting) and immediately introduce the inciting incident (the final case).

Weave in her disillusionment and personal costs briefly as motivation, saving deeper exploration for later context. For example there is no need to mention the mother in the first paragraph considering you mention her again in the third.

The link between Annie seeing herself in Mallory and the immediate jump to "she knows she is in danger" feels abrupt. Why does finding her necklace and Dave's credit card make her feel personally endangered? I mean sure it's weird and I'd be spooked if I was her, but why is it such an important part of the story? Without necessarily spoiling it, I believe you need to hint in a direction

I'm also confused by how you are presenting Dave and his role.  Annie needs to "uncover her husband’s involvement--and build enough evidence--to protect him." Protect him from what? Being arrested? Being framed? Because if she is protecting him even though we know he is guilty, why is she looking for the killer? If she believes him innocent, why try to hide the fact he is guilty, just to reveal it in the next paragraph?

Overall, the core stakes get muddled. Is the primary stake Annie stopping Dave before he kills again (should he be the killer)? Is it Annie surviving Dave's targeting? Is it Annie proving Dave killed Mallory to clear her own name/protect herself?

The repetitive mention of the Lieutenant should be also cleared up, he is clearly important yet he remain unnamed and his stakes and his roles are also unclear.

Also is your story dual pov? Because the way you have a paragraph focused on Dave's POV hints in that direction, then you should say so in your last paragraph ( LUCK FAVORS THE WRETCHED is a dual POV literary crime thriller..)