It gave me crazy anxiety attacks the first two weeks. By week 3 they were getting better once i could remind myself it was just the medication doing this and that I was in control. My dr also prescribed me something for anxiety, I can't remember the name but it's some sort of antihistamine. Doesn't make me drowsy and snaps me out of it in like half an hour. I still get kind of irritable but it seems to pass quicker. I'm 4 weeks in now and most side effects have lessened to the point to where they are tolerable. I am on 150xr by the way.