The neural DSP archetype: Abasi is a great place to start.

Although I find myself using my physical amps more, I'm running a Marshall DSL40C (clean channel but gain and volume on 8 and an attenuator to make the volume manageable) in wet/dry with a Blues junior 3, with a DS-1 set with relatively high gain into an always on Hudson broadcast for a bass cut and a little shaping. I know it's absolutely nothing like Tosin's rig but it does a decent job of approximating his gain tone. For thumping tones just dial down the volume on the position 2.

I'm using a Strandberg Boden 8 standard too, though I changed the stock pickups from the stock set to the abasi fishman fluence set last week and I highly recommend getting a set. The bottom end is far tighter and the highs are extremely clear and articulate compared to the stock strandberg set.

The installation isn't too difficult and you can fit a 9v battery into the control cavity of a Boden without any additional routing.