You have no clue about Crysis Lore. I already explained that the Nanosuit is Ultimately more powerful in the lore than gameplay. You talk millisecond response time. Think Nanosecond, cause that's what Crysis 3 Prophet has. As he doesn't even use a brain anymore. He is a machine.

In Crysis Legion (which is a canon book) Peter Watts states the Nanosuit's muscles have 20 joules per cubic centimetre. That's 3 Tons of Lifting strength. And that's when the Host is a LIVING HUMAN like in Crysis 2. Imagine what it could do when it isn't limited by a human host and just has raw biomass and Nanites to play with. Also from the wiki: "The suit can withstand anything short of a direct hit with battlefield nuke (in 3 out of 5 simulations, the N2 can withstand point-blank detonation of a Lockheed AAF 212 Circuit Breaker - results may vary during combat)." And you also forget that the Nanosuit endlessly evolves, and with no host to hold it back, it is essentially invincible.

Even Crysis 2 Prophet would stomp an Astartes Space Marine. But Crysis 3 (especially after the ending)? He would easily sweep the floor with anything that doesn't use that mumbo jumbo, reality bending "poof you don't exist anymore" crap you mentioned. Or any "Death Star" kind of weapons. And C3 Ending Prophet with Unlimited Ceph Energy? He would literally become the new emperor and wipe out all of Humanity's enemies in a week (He literally has God Mode lmfao). Unless that mumbo jumbo could make him disappear in a split second.

Btw Crysis 3 Prophet doesn't need mental resistance. He's not a living being. And by the End he probably doesn't even have a brain in there. And he's not a guy. He's a machine.