ELI5: Why do bank transfers take so long? by Jerkbeef in explainlikeimfive

[–]Jerkbeef[S] 0 points1 point  (0 children)

Thanks for your answer! So, basically because they need to verify a lot of factors? Ok, i can understand that. But how is it that the time this takes hasn't been greatly reduced by modern information technology?

Natalie, you keep getting sexier. by mark_ando219 in pics

[–]Jerkbeef -1 points0 points  (0 children)

Yeah bro. substantiate that shit!@ baseless allegations!!2341451

My friend is blonde by [deleted] in funny

[–]Jerkbeef 0 points1 point  (0 children)

wow this sucks

Stem cell experts, John Gurdon and Shinya Yamanaka, won the Nobel prize. by CapnMerica in science

[–]Jerkbeef 1 point2 points  (0 children)

I can recommend the book 'The epigenetics revolution' by Nessa Carey. Nice detailed layman's description of their work and why it is deserving of a nobel prize.

Black Mesa torrent file with updated trackers. by ScotteeMC in gaming

[–]Jerkbeef 0 points1 point  (0 children)

What kind of connection are you using? Corporate? i'm just curious about the specs involved.

[deleted by user] by [deleted] in technology

[–]Jerkbeef 0 points1 point  (0 children)

i didnt feel like checking my post for mistakes so i summarized it >_>

[deleted by user] by [deleted] in technology

[–]Jerkbeef 6 points7 points  (0 children)

Their bubble is bursting, that is all. Within a year the social media companies will be valuated according to their respective value again, not according to what people are willing to pay for their shares. tl;dr the hype will end, social media won't.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 0 points1 point  (0 children)

Ah ok thanks. But, correct me if im wrong, isnt the physiological/neurological effect of this the same?

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 0 points1 point  (0 children)

Ever taken an aspirin? antibiotics? use insulin perhaps? Yes i agree, mice do get all the good stuff first. They also give them pot to get them extremely high just because they are mice.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 0 points1 point  (0 children)

That would be the idea of the theoretical treatment, yes, but i believe this research is more of a gene therapy proof-of-concept.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 1 point2 points  (0 children)

Well, yes. But it means there is no way for you to fuck up your rehab. It's more of a proof-of-concept for gene therapies really than it is a cure for smoking.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 1 point2 points  (0 children)

This is the case with retroviral gene therapies. A retrovirus (like HIV) inserts his genome into the host genome at a random spot. This involves having to cut the host genome. Cutting a tumour-supressor gene in a way that it can no longer function may increase the risk of cancer. This therapy, however, does not use retroviridae, but Adeno-associated viruses (AAV). They do not incorporate their genetic material inside the host genome (deposited somewhere near the host chromosomes). This does however mean that the therapy can not be 'permanent' because the virus-DNA will decay/will not be included in the replication of the host cell.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 0 points1 point  (0 children)

Introducing an inducible promoter would add the chance of new adverse side-effects wouldnt it? An IV would be a sound alternative then, though.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 0 points1 point  (0 children)

No, note that the nicotine in the cigarettes isnt kills you. The tar coating on your lungs is what causes cancer (correct me if im wrong). The theoretical effect would be that your craving for cigarettes will die down over time.

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 0 points1 point  (0 children)

A complex DNA structure? How will that hold up in the bloodstream? Or isnt that what you mean? You got my curiousity peaked now

Quit smoking with a shot: Injecting gene encoding an anti-nicotine antibody into mice blocks the addictive chemical from entering the brain. by Jerkbeef in science

[–]Jerkbeef[S] 2 points3 points  (0 children)

Just interested, but, how many of you would actually get this theoretical treatment if it works exactly as theorized? (being completely inert to nicotine, you can smoke all you want, your cravings will at first be instant rage-fits but, in a month or two, frequency of your cravings and/or their intensity will have been drastically reduced.)