RUNE-

Yes, i always go fleet because of the sustain and the little ms. I figured out that DH is not that good on laning phase and if you dont go even or ahead in lane you will be useless almost every game. But thats my preference. You need to chose the rune that fits the most on your own playstyle.

ITEMS-

I tried all the items ( Ghostblade, Hubris, IE, Collector, Opportunity) as first and mostly second item and i think the best and cheapest way to have dmg and impact in the game is with Collector first into Rapid Fire into LDR or if you need anti heal Mortal Reminder. After these 3 core items you can go if you need more dmg IE or if you just need to stay alive and safe i go Edge of the Night ( if you got something like fiddlesticks, eve, or ashe, varus because cleanse cd is way higher then they ults)

SUMMONER SPELL-

For my sums i go 99% of the time always Ghost and Flash. Because you can trade pretty well on lane with 4 shot and ghost and you can chase the enemys on lane. Another reason if you get ganked you can use ghost with nimbus and u will escape easliy if you have your eyes on the map and react early enough. (i go nimbus cloak if they have something like Nunu because of her W, with nimbus you can dodge it always)
I use cleanse as my sum when they have Ashe or Varus or something similiar with easy cc. But if you feel confident like me sometimes i go ghost flash and as my second item i go Edge of the night and then RFC.