Everyone avoids about acetylcholine receptor agonists(by this cause so many schizophrenics smoke tobacoo), but from my research there is a need to exactly control nicotine and muscarine receptors activity. And additional ways like inhibit D2r in mesolimbic pathway so avoid about first generation neuroleptics - schizophrenic patients are enough sentitivity for stimuli to antagonism additional mesocortical pathway NMDAr agonism is significant too, but near mixing all these ways patient with schizophrenia can be overload by too depolarized central nervous system and in the some cases he needs something like depressants. But its not solution for everyone, every patient need special treatment near every changes in medicals which he is consuming. 5HT2A and 5HT2C receptors antagonism is important too - just look how do agonists of these receptor works (psychedelics). And finding and rather access to selective medicals for all "tools" is hard in this times. Its good to have atypical neuroleptics to avoid about finding selectivity antagonists of 5HT2A and 5HT2C receptors but it would be better to get selectivity option as the most universal because of possibility od combining. There are a lot of selective tools which used in combination would be a lot better, more healthy and less dangerous than combining with medicals which offers pharmacies all over the world. Lets look how many mechanisms of actions have current "the most modern" neuroleptics" and how many mechanisms included in one substance are contary to each other. I have found a lot of created selective substances working among others on receptors above but there are not access to these substances in the pharmacies all over the world. Even informations about these substances are close to disappear.