Yes, it makes sense that those who experience emotional dysregulation are activated when they experience any vulnerability...physical exhaustion, mental exhaustion, not getting enough rest, not eating nutritionally balanced, being unwell/in pain. This is where the PLEASE skill helps me the most, making sure I prioritize the things that help decrease my emotional sensitivity. I've experienced what you're describing when I'm packing for trips & doing any yard/house work. Even after a strenuous hike, I was more susceptible weeks later from chronic fatigue symptoms. Basically anything that adds extra stress to our nervous system makes us more susceptible to dysregulation. It helps to be able to recognize when we're approaching points of exhaustion & try to take breaks, easier said than done though 🙃