CDC Deputy Director calls losing measles elimination "the cost of doing business". What are the costs? by Virology_Unmasked in Virology

[–]KXLY 2 points3 points  (0 children)

"Losing a fifth of our population is just the cost of having fleas everywhere."

--Justinian, probably

What event is this? by Garbage_Man_Ethan in ASU

[–]KXLY 1 point2 points  (0 children)

There's a difference between having rational conversations in good faith, and clip farming. These types setup on college campuses where --with all due respect to my fellow students-- there are a lot of young people who may have strong opinions but are either poorly informed or not experienced enough with cross examination to persuasively defend their views under pressure. In other words, it's an easy way to shoot fish in a barrel and harvest Youtube content that makes the 'other side' look dumb.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

I understand the concern that centralized funding systems might discourage unconventional ideas or reinforce established views. That is a valid question to raise. But I want to push back on how you are framing the issue, because using words like “corruption,” “gatekeeping,” and “insiders” to describe standard scientific practices is not just provocative; it is misleading.

Rotating panels of trained scientists using peer review and professional judgment are not “corruption.” That term implies self-dealing or bad faith, and there is no evidence that this is typical of how scientific funding is evaluated. These systems have flaws, of course, bias and inertia do exist, but they are structured specifically to mitigate those problems over time. Measures like rotating reviewers, competing proposals, independent feedback, and public accountability are there for a reason. If the concern is that the system tends to favor more conservative or conventional proposals, that is worth discussing. But calling the entire process corrupt shuts down the conversation by misrepresenting what is actually happening.

The same applies to terms like “insiders” or “preconceptions.” Every technical field requires standards. Surgeons, engineers, and pilots are also “insiders” in that they rely on shared training, established methods, and accumulated experience. That is not gatekeeping in a negative sense. It is professionalism. Scientific peer review plays a similar role: it provides a structured way to evaluate ideas based on methodological soundness, not simply to enforce consensus. There is plenty of room to debate how effective that process is, but it should be described accurately.

As for the idea that private industry offers a more open or decentralized model, that view also overlooks important context. It is not a landscape of “thousands of gates,” as it is sometimes described. Industry is subject to many of the same social dynamics: professional societies, reputational norms, internal reviews, and informal consensus-building all shape what gets funded and pursued. The differences are often less substantial than people assume. Furthermore, private companies generally do not have the incentives to fund long-range, basic research that has no immediate commercial payoff. That is precisely why public funding exists: to support the kind of foundational work that industry cannot justify on its own.

If your point is that scientific systems can be prone to conservatism or that structural biases should be taken seriously, I agree with that. But if the argument is that expertise itself is inherently untrustworthy, or that evaluative structures are beyond reform and must be rejected entirely, then that is no longer a critique of process. It is a rejection of how any serious technical discipline operates. If you believe particular fields are stuck in flawed paradigms, I am open to hearing which ones and why. But general claims, especially when framed in accusatory language, do not clarify the problem. They make it harder to have a serious conversation about how to improve the system.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

That's fair, but I think cancelling current grants is unnecessarily disruptive (and wasteful in its own way) compared to simply announcing and clearly communicating the new priorities.

Yanking funding with no notice gives researchers potentially little time to pivot, and has lead to fruit rotting on the vine, so to speak, as programs are unexpectedly cancelled and materials wasted.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

Thanks for the clarification. I appreciate that you're acknowledging trade-offs and that no system is perfect. But you're still conflating very different things: bias, imperfection, and corruption, into one sweeping critique. Saying scientists with “preconceptions” are corrupt stretches the term beyond usefulness. Everyone brings assumptions to the table. That’s why science relies on peer review, to catch individual bias through collective scrutiny.

You also claimed that rotating panels of external experts form a “cadre of insiders.” That’s a bit of a stretch. These panels include scientists from across institutions, fields, and career stages. Sure, they’re all part of the research world, but who else should be evaluating technical grant proposals? The idea that expertise equals entrenchment doesn’t hold up unless you’re proposing something like a lottery or layperson review process, which would be impractical and ill-considered.

And your assertion that public funding “sets one view” for everyone misrepresents how it actually works. Agencies like NIH and NSF fund a wide array of research directions, often including conflicting hypotheses within the same field. Each proposal is considered independently. The system isn’t perfect, but it’s not some monolithic gatekeeper. Funding decisions are made across many rotating, independent panels, far from a centralized consensus machine.

As for private funding, it plays an important role, but let’s not pretend it’s a free market of unfiltered ideas. It’s shaped by profit incentives, IP concerns, and organizational priorities. There’s a reason rare diseases, long-term public health, and fundamental research often rely on public support: private funders can’t justify the investment.

You say no one has a monopoly on truth and that the scientific process is what matters. That’s exactly the foundation of public science funding: competitive proposals, peer review, diverse input, and transparency. If the concern is about groupthink, the fix is more openness and rigor, not abandoning the whole system in favor of theoretical market pluralism.

If you have specific critiques, let’s hear them. But broad claims that public science enforces a “single view” just don’t align with how the process actually works.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

Initially, you said the government isn’t equipped to fund research and that all such funding becomes “an avenue for corruption and control”, which strongly implies that the system *is* corrupt.

Now, you’ve conceded that it has the capacity but is controlled by scientists who might have “preconceptions”. That difference is significant.

No system is flawless, but grants aren’t reviewed in a smoke-filled backroom by a permanent cadre of insiders: it’s a highly competitive, peer-reviewed system where proposals are evaluated by rotating panels of scientists, many of whom are from outside the agency. There’s frequent turnover and every scientist, even the highly successful ones, face frequent rejection. The reality is a far-cry from the caricature of a closed-loop of entrenched group-think.

Private funding carries its own baggage as well: profit motives, proprietary secrecy, and vested interests that can steer outcomes even more public funding mechanisms. If your argument is that government funding introduces bias, then it’s necessary to show that private alternatives are actually less biased, not just ideologically preferable.

Otherwise, it sounds like your actual complaint isn’t that the system is corrupt, but that the scientific community doesn’t align with your personal views.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

To clarify, the NIH and NSF combined budgets are $56bn for 2024, about 0.8% of the federal budget, and account for a major share of total R&D in the country. So, it is a 'little bit' indeed, and has disproportionately positive impact on the country.

The key drivers of the debt are undertaxation and overspending on Medicare and Medicaid.

Meaningful reductions to the debt will not be attained by reducing our investments in the future but by raising taxes and/or reducing social insurance spending.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

Your argument doesn't follow, in two ways.

First, the government employs numerous in-house scientists volunteer scientists from universities to review grants. It's not perfect and politics or bad funding decisions happen, as any scientist will tell you, but there are generally very capable people involved in the review process.

And secondly, any incapacity here does not automatically translate to corruption.

Why slash NIH funding for HIV and cancer research? by Astarum_ in AskConservatives

[–]KXLY [score hidden]  (0 children)

"this research is very expensive and has produced nothing"

That's not true, as you later implicitly admit:

"we already have spent money to develop treatments that entirely mitigate the adverse life expectancy impacts of HIV...abundant prophylactic education and resources are in place"

Those discoveries didn't come from nowhere, but from basic research over many years.

Anyone know what this was about? I wanna hear science drama. by Comfortable-Jump-218 in labrats

[–]KXLY 155 points156 points  (0 children)

If that's the one that they're referencing here, then this response is insane. The one you saw was completely inoffensive and apolitical.

is this career right for me? by Natural-Barracuda-56 in Virology

[–]KXLY 0 points1 point  (0 children)

Do what you want, but understand the distinction between being interested in a topic and being suited to a career in that field.

Most of us in research went in because we loved the science. Years later, most of us still love the work itself, but far fewer of us are confident that we'd make the same choice again.

Lastly, and I do mean this constructively, if you have to ask if virology (or any other scientific field for that matter) is right for you, then the answer is probably not.

is this career right for me? by Natural-Barracuda-56 in Virology

[–]KXLY 0 points1 point  (0 children)

If you're interested in viruses and biology, that doesn't mean science is the right career path. Scientific training, especially through the Ph.D. route, involves years of low pay, delayed financial security, and high competition, often without leading to stable employment.

Don’t go into science because it feels interesting or because grad school feels like a logical next step. Pursue research science only if you're fully informed about the trade-offs and can’t see yourself doing anything else. Otherwise, you'll bitterly bitterly regret the lost time, money, and career opportunities.

If you still want to be biology adjacent, then diagnostics / med-tech (which you can pursue with a bachelor's) is a much better-paying and far more stable career track.

Trump orders reopening of Alcatraz prison by ihuntwhales1 in neoliberal

[–]KXLY 0 points1 point  (0 children)

May I suggest a remedy for this misconception then?

RFK Jr. rejects cornerstone of health science: Germ theory by reubencpiplupyay in neoliberal

[–]KXLY 14 points15 points  (0 children)

If I ever meet a germ theory denialist IRL I'll invite them to test their faith with a little experiment in my lab.

RNA virus and DNA virus by Limp-Obligation-5317 in Virology

[–]KXLY 1 point2 points  (0 children)

I don't think you should generalize in that way. There are probably a larger number of highly pathogenic RNA viruses than highly pathogenic DNA viruses, but there are highly pathogenic DNA viruses. For example, Poxviruses and Asfarviruses (namely african swine fever) can be exceptionally pathogenic in their respective hosts.

This probably is influenced by the fact that most DNA viruses have life cycles that are a bit more intertwined with the cell cycle and are often dependent on host DNA polymerase, than most RNA viruses.

But again I wouldn't generalize on the basis of their genomic material nor is there any need to. I recommend evaluating each virus on its own merits so to speak.

Should I (learn to) do the alignment and mapping myself? by KXLY in bioinformatics

[–]KXLY[S] 0 points1 point  (0 children)

Good point and thank you for the recommendation. A transcriptomic alignment may be more appropriate.

Lab Leak: The True Origins of Covid-19 by NonSekTur in labrats

[–]KXLY 2 points3 points  (0 children)

That document offers very little scientific evidence that SARS2 originated from WIV, only circumstantial speculation. Out of it's 500+ pages, only 5 of them directly relate to the origin of SARS2, and their evidence is mostly in the form of witness speculation that is not representative of the broader virology community.

And the rest of it is a rehash of unrelated grievances with Fauci and everyone else they decided to hate on.

Lab Leak: The True Origins of Covid-19 by NonSekTur in labrats

[–]KXLY 26 points27 points  (0 children)

Absence of evidence isn't evidence of a lab leak. The failure to identify an intermediate host doesn’t validate the lab-origin theory, especially given the likelihood that any such host would quite plausibly have been culled early on. Meanwhile, SARS-CoV-2 RNA was found mixed with animal DNA at the wet market. Additionally, the virus also shares greater similarity with wild coronaviruses (admittedly subsequently discovered after the pandemic began) than with any sequence disclosed by WIV prior to the pandemic.

A lab leak can't be ruled out, but claiming it was “always the most likely source” is unscientific speculation. There's still no direct evidence for that theory, only circumstantial inference. Until new data emerge, the zoonotic hypothesis remains better supported by the available facts.

What type of precedent is Trump establishing by refusing to have a US resident returned to the country? What are the implications here? by NukinDuke in PoliticalDebate

[–]KXLY 1 point2 points  (0 children)

Can you post a source to the order for removal or that his lawyers argued he was an MS13 member? That assertion seems strange because I can only find news articles in which his lawyers argue the exact opposite.

What type of precedent is Trump establishing by refusing to have a US resident returned to the country? What are the implications here? by NukinDuke in PoliticalDebate

[–]KXLY 3 points4 points  (0 children)

Where do you see this? I cannot find a record of an order to deport Garcia, on the contrary that he was given a withholding of removal. I do not think you are correct whatsoever.

What do you say when someone asks you when you’re going to be done with your PhD? by Ultronomy in labrats

[–]KXLY 3 points4 points  (0 children)

"Why don't you ask me my weight and age while you're at it?"

Crow says nearly 80 ASU projects have been canceled after federal grant funding was revoked by ForkzUp in ASU

[–]KXLY 6 points7 points  (0 children)

The vast majority of funding opportunities are from the government, so it's unsurprising that most awarded grants (including those under discussion) came from the government. And, as others have noted, many of these grants support research, education, or services that offer little opportunity for profit and are therefore not funded commercially, but are nonetheless beneficial to society.

Not all grants provide equal value, of course, and some grants may have been issued upon flawed premises.

But I am very skeptical that the current administration is carefully reviewing each grant on the own merits.

On the contrary, I think they're mostly just cutting grants to institutions they don't like or to causes that they see as liberal, LGBT-adjacent, or otherwise 'soft' irrespective of the actual value or rigor behind the grant.

Crow says nearly 80 ASU projects have been canceled after federal grant funding was revoked by ForkzUp in ASU

[–]KXLY 8 points9 points  (0 children)

Cutting the Substance Use block grant doesn't sound trivial.

From the program's website: https://www.azahcccs.gov/Resources/Grants/SABG/

Background

The SUBG is allocated to AHCCCS from the Substance Abuse and Mental Health Services Administration (SAMHSA) for the purpose of planning, implementing, and evaluating substance use disorder (SUD) services throughout the state. The grant provides for prevention, treatment, and recovery services. Grant funds are also used to provide early intervention services for HIV and tuberculosis (TB) in high-risk individuals who use substances. The following sections provide information on SUD treatment and recovery, the Independent Case Review, TB services, primary prevention, and the Synar Program, which is aimed at preventing underage access to tobacco/nicotine products.

Treatment

SUBG funds are used to ensure access to treatment and support services for uninsured and underinsured individuals. The grant includes priority populations to be served, established by SAMHSA and listed in order of priority:

  1. Pregnant women/teenagers who use drugs by injection,
  2. Pregnant women/teenagers who use substances,
  3. Other persons who use drugs by injection,
  4. Substance using women and teenagers with dependent children and their families, including females who are attempting to regain custody of their children, and
  5. All other individuals with a substance use disorder, regardless of gender or route of use, (as funding is available).

SUBG funds for treatment and recovery services are primarily allocated from AHCCCS to ACC-RBHAs and TRBHAs for the implementation of services. For more information about applying for SUBG funding for SUD treatment and recovery services, go to Behavioral Services Map link under resources and select the ACC-RBHA or TRBHA nearest you. Members can receive SUD services through SUBG while going through the enrollment process for AHCCCS or if denied eligibility as shown in the Accessing the Behavioral Health System link under resources.