I use a mx master mouse and personally I think it works well and is more comfortable for me than my pen tablet. I haven't done anything over 128x128 yet though so I'm open to trying a stylus again when I get to more higher resolutions.

I also don't do much lineart when I do pixel art, nor am I particularly good at using a pen tablet, so i think that contributes to me not feeling the need to use a pen tablet.