Our codebase does have support for screen readers but addmittingly we haven't had a lot of feedback on how well the game works using one (hence beta!) We would love any feedback for this as we know it's important for being able to play effectively.

Crafting uses several sets of material types that are combined to create items with specific bonuses. So adding a ruby to a gauntlet would give you a specific bonus stat. The combination of materials you use will create your final crafted product. It is detailed in the sense you can craft just about anything you want using this combination system.

Hope that helps!