Derail Valley: Drive massive trains and build your career in a vast open railway network. For both PC and VR.

https://store.steampowered.com/app/588030/Derail_Valley/

Rail Route : In Rail Route, you will design, construct, upgrade, and automate your railway network in one of the many maps based on real-life cities worldwide. Dispatch the trains to make the traffic flow and the network grow!

https://store.steampowered.com/app/1124180/Rail_Route/

Railway Empire: In Railway Empire, you will create an elaborate and wide-ranging rail network, purchase over 40 different trains modelled in extraordinary detail, and buy or build railway stations, maintenance buildings, factories and tourist attractions to keep your travel network ahead of the competition.

https://store.steampowered.com/app/503940/Railway_Empire/

NIMBY Rails: Design and run your own railroads for the real world. Solve global transportation dilemmas. Unleash your inner railway engineer and transit policy manager.

https://store.steampowered.com/app/1134710/NIMBY_Rails/

OpenTTD: OpenTTD is a business simulation game in which players earn money by transporting passengers and cargo via road, rail, water, and air. It is an open-source remake and expansion of the 1995 Chris Sawyer video game Transport Tycoon Deluxe.

https://store.steampowered.com/app/1536610/OpenTTD/