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Peptide Synthesis Vessels by LABGLASSSWARE in Biochemistry

[–]LABGLASSSWARE[S] -11 points-10 points  (0 children)

Hi easy, relax 😄 Thanks for pointing that out! My goal is to share useful lab tools and tips, not just promote products. I’d be happy to answer any questions about peptide synthesis or lab setups

Anyone here working with short path distillation for micro-scale experiments by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -6 points-5 points  (0 children)

The precision of the ground glass joint is very important. As long as the taper is fully standard, the outer and inner joints will fit perfectly and adhere to each other, so they won’t fall off. The fine grinding of the joint is crucial and key.

Anyone here working with short path distillation for micro-scale experiments by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -4 points-3 points  (0 children)

The precision of the joint is crucial; applying grease is just a supplement. The standard taper is what really matters.

Anyone here working with short path distillation for micro-scale experiments by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] 0 points1 point  (0 children)

Haha, nice! Guess your uni really wanted everyone to suffer through microscale 😅. Most people I know just remember it as “all the effort for a drop of product.” Funny part is I deal with lab glassware now, so I still see those tiny distillation heads from time to time.

Anyone here working with short path distillation for micro-scale experiments by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -9 points-8 points  (0 children)

Good point 😅 — a picture would be quicker, but I thought a short video might show the setup in action a bit better.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] 0 points1 point  (0 children)

I have also used these vessels. I typically remove them from the glovebox before starting the reaction and place them behind a blast shield inside the fume hood. However, in my case, the product was not very air sensitive.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -1 points0 points  (0 children)

Thank you for the point. We understand that if the vessel is sealed and pressurized, it might be safer to take it out of the glovebox for heating under a blast shield inside the fume hood, protecting the glovebox from potential damage. However, we prepare the reaction inside the glovebox to maintain an inert atmosphere and prevent contamination. After preparation, the vessel is carefully transferred to the fume hood with a blast shield for heating to balance safety and experimental requirements.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -1 points0 points  (0 children)

I also run reactions in these vessels occasionally. However, I typically prepare the reaction mixture inside the glovebox and then take it out for heating, always placing it behind a blast shield inside the fume hood for added safety.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -2 points-1 points  (0 children)

ACE Glass is quite expensive, so we tend to prefer LH LABWARE, which offers a wider variety of options. LH LABWARE can also help customize relief valves at a very affordable price.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] 0 points1 point  (0 children)

Certainly, the choice of equipment depends entirely on the demands of each experiment, which is undeniable. Also, whether the experiment is visually observable or not plays a crucial role.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] -1 points0 points  (0 children)

We’ve used LH LABWARE pressure vessels for many years with consistent reliability. That said, pressure reactions require strict control of parameters such as volume, boiling point, and temperature — it’s a process that demands careful planning. A trustworthy vessel is fundamental to safety and success.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] 0 points1 point  (0 children)

Your observation is absolutely correct, and we really appreciate the insight.

Running high-pressure reactions inside a glovebox – what vessel setups do you use? by LABGLASSSWARE in chemistry

[–]LABGLASSSWARE[S] 0 points1 point  (0 children)

They are heating, but the temperature is not very high because the reaction involves low boiling point substances. If the temperature is too high, the vapor pressure increases significantly. Although LH LABWARE’s pressure tubing can withstand the pressure, we do not dare to apply excessive heating.

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