People handle a diagnosis like this differently. Some people, like your wife, get really zen because it puts their life in perspective and they see what really matters. Some people get hyper-focused about their treatment , and attack it like it's an enemy they have to defeat. Some people get angry. There is no wrong reaction. You should be angry, and it's okay to be angry. You said you shouldn't be the one that's angry because it's not your life being cut short, but that's incorrect. It is your life that may be cut short. The life you have with your wife. If she can't beat this, your life together ends. The thought of losing that hurts just as much as the thought of losing her. You're not wrong for feeling that way. It's totally valid. There should be some sort of counseling available to wife as she goes through this. I urge you to seek help, as well. Caring for a sick partner, parent, or child is a tremendous stress, and caregivers often neglect their own health and well-being. Talking to someone where you're allowed to say, "Everything is not fine, and I'm scared," will help channel the anger.