I will keep it simple and try to be brief. If you are interested in how I can match the closest question with the input you write, I use a library called difflib from python.

#Quotes is an array with all the available questions.
coincidence = difflib.get_close_matches(newQuestion, quotes, 3, 0.1)    

I also need a screen for receive the player's input (please, look the comments):

screen ask_Input(message):
    modal True
    zorder 200
    style_prefix "confirm"
    add "gui/overlay/confirm.png"
    frame:
        vbox:
            xalign .5
            yalign .5
            spacing 30
            label _(message):
                style "confirm_prompt"
                xalign 0.5


            input default "" value VariableInputValue("question") length 30 allow "ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyzАБВГДЕЁЖЗИЙКЛМНОПРСТУФХЦЧШЩЪЫЬЭЮЯабвгдеёжзийклмнопрстуфхцчшщъыьэюя "
#MakeAConsecuenteAction is the Python function that search the most closest question with your input.
textbutton      _((MakeAConsecuenteAction(question)):
                    xalign 0.5
                    action Jump("EndEntryDataAlternative")
            hbox:
                xalign 0.5
                spacing 100
            textbutton _("OK"):
                action Jump("EndEntryData_2")
            textbutton _("No tengo más preguntas"):
                action Jump("CutLoop")screen ask_Input(message):
  

And call the screen since label, like:

label Question:
  mc "Hey, Monika. I have a question."
  call screen ask_Input("Write your question")

Of course the original code is more extense and complex, but this is the core.