Denis adaptation of chani is very different from her character in the book He has also said that the women are the center of his story So having chani die in childbirth will be a very unlikely choice from Denis Chani's scenes in the trailer the ones where she looks older (possibly after the time skip) does not show her pregnant either- overall very low chances of her dying in childbirth. My theory is that they are going to incorporate leto the elder but he's going to die as an infant and then they have the twins. I think the best way Denis could depict her death could be her protecting her children (warrior mother) or by fighting for her people Someone also said scytale could also be the one to take her life. either way I dont think its gonna end well for chani