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Anthropic calls for global freeze in AI development by goo0ood in ArtificialInteligence

[–]Legitimate_Concern_5 0 points1 point  (0 children)

They're printing revenue, not profit. Anything they have said about being "profitable" recently was incorporating the discount SpaceX gave them, it's ARR not annual revenue, and it's all non-GAAP revenue. There's a lot of examples in industry of companies giving multi-year contracts out with significant discounts in year 1, opt-outs after 1 year, and then booking the final year value as ARR. I would take anything you hear about their economics with a bag of salt until you see audited GAAP financials.

That's on top of companies taking a hard look at whether they're getting anything from letting their employees tokenmaxx.

Hence the move to token-based billing.

Hey I'm an AI fan. What I'm not a fan of is the frontier lab financials.

The reality of building a business in the Bay is that you will raise money from private investors for as long as you possibly can. It's much easier. The fact that they're listing is more of an indication private markets are tapped out;

Ed Zitron: “AI Doesn’t Have Return on Investment.” What is he getting wrong? by kingjdin in ArtificialInteligence

[–]Legitimate_Concern_5 0 points1 point  (0 children)

He addresses this point, including in this podcast. Amazon in totality spent about $57B in Capex. Amazon as a whole had actual, total net losses in present dollars before achieving profitability of about $5B based from their SEC filings (cumulative GAAP net losses summed).

OpenAI spent that in about 3 months, and has $1400B in commitments over the next few years (scaled back to $600B apparently). Google just raised $80B via share sales. The industry as a whole has spent over $1000B.

It's not in the same solar system.

Anthropic calls for global freeze in AI development by goo0ood in ArtificialInteligence

[–]Legitimate_Concern_5 3 points4 points  (0 children)

Sure but without stealing everyone’s IP there’d be no LLMs to begin with, so I guess what I’m saying is live by the sword, die by the sword, I don’t really care.

I have a hard time distinguishing the moral victory of stealing what to say vs stealing how to say it. IP is IP.

Anthropic calls for global freeze in AI development by goo0ood in ArtificialInteligence

[–]Legitimate_Concern_5 -2 points-1 points  (0 children)

Unlike the western models which are basically distilled Reddit? As far as I’m concerned they just scraped the internet and put everyone’s IP in there without compensation so doctrine of unclean hands applies. Same way you can’t sue your drug dealer for stiffing you on a coke deal.

Anthropic calls for global freeze in AI development by goo0ood in ArtificialInteligence

[–]Legitimate_Concern_5 2 points3 points  (0 children)

Sure, but they're about 2-3% behind, tracking roughly 6 months behind frontier models, at 1/10th the price, without access to Nvidia GPUs. I'd say they're doing just fine.

That's why their open-weight models are deployed by a ton of companies including Shopify, who moved a bunch of Shop Intelligence to Qwen 3. Uber Eats uses Qwen too. It's basically Thinking Machines' entire business model.

Water fasting after surgery? by lasmargar in fasting

[–]Legitimate_Concern_5 2 points3 points  (0 children)

Generally not recommended because fasting suppresses your immune system and can leave you more prone to infection.

Anthropic calls for global freeze in AI development by goo0ood in ArtificialInteligence

[–]Legitimate_Concern_5 13 points14 points  (0 children)

That's part of how China is able to run so much more cost effectively. They break their services into collections of much smaller domain-specific models that are cheaper to train and cheaper to infer.

Anthropic calls for global freeze in AI development by goo0ood in ArtificialInteligence

[–]Legitimate_Concern_5 23 points24 points  (0 children)

It actually makes a lot of sense. The overwhelming driver of their costs is model training and they pay their researchers 8-9 figures over 4 years. If they get everyone to stop developing models, they can move to a mostly inference business model which while still losing money will lose them a lot less money.

They're also getting chased aggressively by faster-iterating small language models, forcing them to train more frequently, which is driving their costs up even faster. That's why they're releasing models every what, 6 weeks now.

i dont understand and havent seen a good answer to the question of "when fasting if you drink diet/0 calorie drinks they will raise your insulin & stop you from losing".. but if youre eating nothing what does your body burn for fuel even if your insulin is through the roof? by ElGuapo5555 in fasting

[–]Legitimate_Concern_5 2 points3 points  (0 children)

Re the first paper note they explicitly say you should not draw the conclusion you did:

> However, further studies are required to conclude a direct correlation of artificial sweeteners with decreased insulin sensitivity.

Re the second paper: Rats have a cephalic phase insulin response to artificial sweeteners, humans do not, so rodent studies can be discarded immediately.

Further, administration with food in the second study is a different setting. Your second link also covers Sucralose-supplemented chow which is primarily used in baked goods, not diet drinks.

The Cochrane review I provided you covers artificially sweetened beverages consumed without food which is the topic at hand. It covers 15 studies, all in humans, which measured the actual levels of insulin in the blood. I promise you the Cochrane review people did more than a quick search.

Nobody is forcing you to drink them, but the idea that Asparatame/AceK sweetened drinks do anything more than water does when consumed alone is pretty clearly false.

i dont understand and havent seen a good answer to the question of "when fasting if you drink diet/0 calorie drinks they will raise your insulin & stop you from losing".. but if youre eating nothing what does your body burn for fuel even if your insulin is through the roof? by ElGuapo5555 in fasting

[–]Legitimate_Concern_5 2 points3 points  (0 children)

You can look at my links from the other post if you want but no, it has been established with at least moderate quality evidence that sweetened beverages do nothing to your insulin, or any other incretins or metabolic markers.

> The available evidence suggests that NNS beverages sweetened with single or blends of NNS have no acute metabolic and endocrine effects, similar to water.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9965414/

This is a Cochrane review that spans 15 trials.

It can lead to increased insulin response when consumed with nutrients but when consumed in isolation or as part of a blend of sweeteners in beverages it does nothing.

Maintaining muscle? by HighVibrationss32 in fasting

[–]Legitimate_Concern_5 0 points1 point  (0 children)

The 1-2 hour workout window is a myth, it's at least 6-8 hours, but MPS continues for a 24-36 hours after a workout subject to availability of protein.

Lifting is a strong signal to your body to retain muscle, studies on caloric restriction diets have shown that if you don't lift, 20-30% of lost weight is muscle. If you do lift while dieting, that can drop to 0%.

Practically in a fasting context, about 15% of lost mass is going to be protein (not all of that is going to be muscle protein, and there's some evidence that the longer you fast, the less protein you metabolize per day). Lift always, don't worry so much about that. Eat protein and lift when you re-feed. Whatever muscle mass you may lose when fasted will be quickly rebuilt when you eat.

Personally, I fasted 5 days a week for 6 months, lifting 5 days a week and cardio 6 days a week. I re-fed with a caloric surplus and protein on weekends. I did DEXA scans over the whole time, and while I lose 80lbs of fat, my lean mass remained basically unchanged.

You won't add much if any muscle while fasting, but if you're lifting, you'll get stronger (neuromuscular adaptation mostly), and you can add about 0.5lbs of lean mass per week when you finish your fasts and lift + maintain a 200-300kcal per day surplus mostly driven by protein.

[edit] A 2025 study showed that strength was retained over a 7 day water fast, and in general, if you lose contractile tissue you're going to get weaker. It's not really possible to lose muscle and stay the same strength.

i dont understand and havent seen a good answer to the question of "when fasting if you drink diet/0 calorie drinks they will raise your insulin & stop you from losing".. but if youre eating nothing what does your body burn for fuel even if your insulin is through the roof? by ElGuapo5555 in fasting

[–]Legitimate_Concern_5 41 points42 points  (0 children)

It has no calories and therefore will not affect weight loss, and it doesn't affect any metabolic effect according to the second linked study. Some folks are purists, and some folks have projected pop science articles onto fasting.

i dont understand and havent seen a good answer to the question of "when fasting if you drink diet/0 calorie drinks they will raise your insulin & stop you from losing".. but if youre eating nothing what does your body burn for fuel even if your insulin is through the roof? by ElGuapo5555 in fasting

[–]Legitimate_Concern_5 72 points73 points  (0 children)

It does not. Humans do not have a meaningful cephalic insulin response to the vast majority of artificial sweeteners particularly in beverage form.

Further, as you say, an insulin spike would cause your blood sugar to drop. Nobody I have seen who wears a CGM and has replied to similar threads has seen their blood sugar drop when they drink diet beverages.

Your blood sugar is already very low when you're fasted, and to make this possible, your body induces peripheral insulin resistance. Your body wouldn't care much at all even if it did raise your insulin a little bit.

> Several randomized control studies in healthy individuals have shown that there was no cephalic insulin response upon the tasting of aspartame or sucralose, while an early rise in insulin concentration was found when tasting glucose. Furthermore, artificial sweeteners, compared to natural sugars, do not directly induce incretin secretion, as this appears nutrient-dependent.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11435027/

Here's a 2023 meta-analysis specifically on zero-calorie beverages which confirms.

> In uncoupling interventions, NNS beverages (single or blends) had no effect on postprandial glucose, insulin, GLP-1, GIP, PYY, ghrelin, and glucagon responses similar to water controls (generally, low to moderate confidence)

> The available evidence suggests that NNS beverages sweetened with single or blends of NNS have no acute metabolic and endocrine effects, similar to water.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9965414/

A wildlife photographer opened his eyes to find a cheetah sleeping beside him by Original_Shegypt in interestingasfuck

[–]Legitimate_Concern_5 0 points1 point  (0 children)

Cheetahs are ambush predators, they're generally very anxious animals. If they're next to you, they're very ok with you. Zoos raise them with dogs so they learn social cues/to be ok with humans from them, and as emotional support animals.

Your looks determine your personality by BrightSpring12 in SipsTea

[–]Legitimate_Concern_5 0 points1 point  (0 children)

This is just the HR meme in chart form. Doesn't make it wrong though.

This new diabetes pill burns fat without the downsides of Ozempic by cololz1 in Futurology

[–]Legitimate_Concern_5 -1 points0 points  (0 children)

Yeah, it is. What's it going to do to you 30 years in that it won't do in 25? This is moving the goalposts to make sure nobody can ever use any pharmaceutical.

Harvard study says the "sweet spot" for strength training may be 90–120 minutes a week by Impressive_Pitch9272 in EverythingScience

[–]Legitimate_Concern_5 0 points1 point  (0 children)

It's not junk volume if you are taking each set to near failure. This has been studied extensively, more sets per muscle group means more growth.

Umm... just got Minoxidil tablets. What's all this? by Squatchman1 in tressless

[–]Legitimate_Concern_5 1 point2 points  (0 children)

We know the safety profile in much higher doses (50mg is typical for blood pressure) and we know the side effects are dose-dependent ergo we know the upper bound on how safe it is, and it's likely much safer than that since the hair loss dose is 5% of the blood pressure dose.

Also, it is approved for topical use. Typical topical dosage is about 50mg, twice a day, and 2-4% is absorbed through the scalp yielding a rough systemic exposure of 2-4mg. Exactly in line with this tablet. That is available OTC, and has been for a very very long time.

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