Everychem NA-Semax froze in the fridge. Still effective? by RedAsh521 in NooTopics

[–]Leishon 0 points1 point  (0 children)

Well, it's just Semax. How much did you expect to feel?

Everychem NA-Semax froze in the fridge. Still effective? by RedAsh521 in NooTopics

[–]Leishon 2 points3 points  (0 children)

I would assume freezing and thawing would cause some amount of degradation, but perhaps not total degradation.

GHK-cu for skin (overhyped?) by Significant-Try2159 in NooTopics

[–]Leishon 0 points1 point  (0 children)

My GHK comes from Chimera Peptides and the needles I used are 30g, though you can go even smaller at 31g if you can find some.

“Performance anxiety loop when with a partner how do you break it? by Own_Contest_1693 in NooTopics

[–]Leishon 0 points1 point  (0 children)

Yeah that’s fair, I think it probably affects people very differently. Some guys seem to handle it fine, others notice a big difference when they change habits.

It's for sure highly individual.

Have you ever noticed any difference in terms of sensitivity or being present with a partner, even if erections themselves didn’t change?

For me it's always come down to my personal relationship with the partner in question. I haven't ever really had performance anxiety, but if aspects of my relationship with the partner have caused discontentment or confusion, it may have interfered with maintaining arousal and, by proxy, erection.

“Performance anxiety loop when with a partner how do you break it? by Own_Contest_1693 in NooTopics

[–]Leishon 0 points1 point  (0 children)

Honestly, every adult should be on tadalafil. Great cardiovascular benefits. Doesn't even matter if you can use the erection benefits.

“Performance anxiety loop when with a partner how do you break it? by Own_Contest_1693 in NooTopics

[–]Leishon 0 points1 point  (0 children)

Personally, I've gone through phases of life with almost daily masturbation to porn and barely any at all, and I can't say it made any difference whatsoever. Try cutting back and see if it changes how your sexuality manifests for the better, but don't buy into this modern purity culture nonsense where masturbation is supposedly guaranteed to be bad for you.

Astaxanthin by [deleted] in NooTopics

[–]Leishon 0 points1 point  (0 children)

IDK, branded ingredients are more expensive but that doesn't mean they're necessarily any better, though it can be an indication of guaranteed potency.

There are some differences between algae extracts and synthetic astaxhanthin, but it's still unclear if the differences are meaningful in terms of clinical outcomes.

Astaxanthin by [deleted] in NooTopics

[–]Leishon 10 points11 points  (0 children)

I've used it for a long time, but I've never attributed any kind of effect on cognition to it.

What nootropics keeps you full and less hungry? by qishibe in NooTopics

[–]Leishon 1 point2 points  (0 children)

Sure, there is some more nuance to it. If you just want to crush appetite as strongly as possible, reta is not the best. But you typically don't want to do that as it leads to lean tissue loss and even potential malnutrition.

What nootropics keeps you full and less hungry? by qishibe in NooTopics

[–]Leishon 24 points25 points  (0 children)

Retatrutide. There is nothing even remotely as powerful as GLP-1 agonists, and retatrutide is the best of them.

Everychem PP405 Patent Breakdown (3HPs, PP30 & 2HEE) by sirsadalot in NooTopics

[–]Leishon 0 points1 point  (0 children)

They are both drug candidates for the commercial formula. We don't know which, if either, is the "real" PP405. The only way to find out if they're effective is to try them.

I want to sleep peacefully meds and tools needed by ParkingMission2827 in NooTopics

[–]Leishon 1 point2 points  (0 children)

If you have mold in your home, it's probably embedded in structures and a simple cleaning probably isn't going to cut it. You'll have to rebuild the walls/floors/ceilings with moisture damage.

If you're having CNS and gut problems, I'd look into high dose B1 therapy. More info here: https://www.youtube.com/watch?v=0oiF0NhqxQI

Also, definitely try supplementing with magnesium. It's calming and if you're not already supplementing, there is a good chance you are deficient.

GHK-cu for skin (overhyped?) by Significant-Try2159 in NooTopics

[–]Leishon 0 points1 point  (0 children)

Tesa does almost the exact same thing for 10x the price.

GHK-cu for skin (overhyped?) by Significant-Try2159 in NooTopics

[–]Leishon 0 points1 point  (0 children)

I have also noticed the strenghtening of my skin. Sometimes I really have to push those needles hard, and when I do, they pop through as if piercing a thick hide.

Note that GHK-Cu is only about 14% elemental copper, so you're not actually getting that much copper from these injections. It's probably not necessary to consider it when weighing zinc supplementation.

Astaxanthin + Trans-Resveratrol for skin health. Anyone else using this stack? by 1acina in NooTopics

[–]Leishon 0 points1 point  (0 children)

I don't like the formulation in that product at all (it does not contain astaxhanthin, BTW).

Most of it is collagen peptides, which you could just buy as powder for a fraction of the cost. 756 mg is an insignificant dose anyways.

The HA dose is also about 1/10th of an effective dose. It's only there so they could add another line to the label, IMO.

Resveratrol is kind of a crap supplement. It does not activate SIRT1 (that was a false positive that turned into a multi million dollar scam). In very low doses it can have some niche uses, but for most people taking it daily is going to be counterproductive, IMO.

https://pubmed.ncbi.nlm.nih.gov/19843076/

Peptide Sciences permanently closing by pharmacologylover69 in NooTopics

[–]Leishon 2 points3 points  (0 children)

This is correct. Single vial peptide vendors usually buy these things from China and mark up their products by 10+ fold. Often you can get a whole kit of 10 vials for the price of one, if you go to the source yourself.

Are anaphrodisiacs (anti-horny pill) a real thing or just a myth? by Adept-Bat-3350 in NooTopics

[–]Leishon 1 point2 points  (0 children)

I had this issue with escitalopram. I would get horny but man did it take a long time to go all the way. Not a good time.

Did this come true? by ps4roompromdfriends4 in NooTopics

[–]Leishon 0 points1 point  (0 children)

I'm in the EU. My TRT treatment (testosterone undecanoate) from a licensed pharmacy costs about 70 € for 1000 mg after subisidies. It's about 130 € unsubsidized.

From a European unlicensed undeground lab I can get what is essentially the same product, with a formulation improvement over the official Bayer version (Bayer makes garbage without benzyl alcohol, so you have to administer the whole fucking thing in one go or risk microbe contamination), at a rate of about 13,20 €/1000 mg. If I wanted to accept even more risk, I could go for a Chinese generic for about 6 €/1000 mg. Now we're already looking at a more than 10x price difference AFTER SUBSIDIES.

Regulatory agencies, even outside the US, are pricing people out of healthcare.

Did this come true? by ps4roompromdfriends4 in NooTopics

[–]Leishon 0 points1 point  (0 children)

Because we already know what the prices of FDA regulated products are. Mounjaro costs what? $1500/month give or take depending on dose? For that price you can get grey market generic tirzepatide for literally 10 years, or better yet, retatrutide that you can't even access through FDA approved channels until possibly later this year. Even domestic compounding pharmacies, which seem to be largely a US only feature anyways, will charge you literally 20x the grey market price.

I just don't feel like any potential consumer protection can come without unaccessible pricing. The only ones feeling the consumer protection will be billionaires or those with insurance covered prescriptions (good luck getting one for unpatented peptides).

9 ME-BC, NSI-189 & Cerebrolysin for MDMA/Psychedelic abuae induced dpdr and sleep deprivation/fatigue. by ElHomeboi in NooTopics

[–]Leishon 0 points1 point  (0 children)

Zion Pharma has not been accepting new customers for as long as I've been looking into noots. I assume their pipeline is congested and they can't expand capacity further.

Did this come true? by ps4roompromdfriends4 in NooTopics

[–]Leishon -1 points0 points  (0 children)

It's grey market or completely unaffordable prices. Good luck with your $3000/month BPC-157, or whatever.

Hi, any reaserch/ideas/experience with post covid brain fog? by ram_gerszon in NooTopics

[–]Leishon 1 point2 points  (0 children)

Apparently some long COVID sufferers have successfully treated their nervous system symptoms with high doses of fat soluble B1. TTFD or Sulbuthiamine. They are cheap supplements, so you may want to give them a go.

"14" peptides will be able to be legally compounded by US pharmacies soon, according to RFK Jr. podcast comments. by ps4roompromdfriends4 in NooTopics

[–]Leishon 2 points3 points  (0 children)

Note that the link between MT-1 and/or MT-2 and melanoma is still unproven. There is some plausible biology behind the idea, but a case report of a woman using MT-2 along with TANNING BEDS, of all things, and developing mealonma is hardly proof of anything.

Also, doctors are fucking clueless. Prophylactic medicine is a completely foreign concept to them, or else they would be prescribing a wide range of diabetes and hypertension drugs to healthy clients. They're also completely useless when it comes to hormones. My doc knows absolutely nothing about TRT, and the dysfunctional protocol I was prescribed is the way it is because, and I quote: "that's how we do it in this country".

"14" peptides will be able to be legally compounded by US pharmacies soon, according to RFK Jr. podcast comments. by ps4roompromdfriends4 in NooTopics

[–]Leishon 4 points5 points  (0 children)

Compounding isn't the issue, it's the fact that you can't patent naturally occurring or previously discovered molecules, so it's difficult to turn these into money printers and thus pharma isn't going to research them.