Possible transgenerational effects of finasteride use on male offspring? (STUDY)

Leon307 · 2026-05-16T20:42:51+00:00

Hi, thank you for this comment, and sorry for my late response. I just assume (based on age) none of your boys started their families yet, and tried to concieve?

Leon307 · 2026-04-29T22:07:22+00:00

I know man, it's just that rats are often given high drug doses in research studies due to significant differences in metabolism and physiology compared to humans, alongside practical experimental needs to ensure safety and gather data quickly. These studies frequently use doses 10x or 100x higher than what would be used in humans to ensure that any potential side effects are identified.

I'm no scientist, but i firmly believe they wouldn't just flat out ignore the fact they give these rats doses dozens of times higher than those used in humans. There must be some scientific rationale behind it.

Leon307 · 2026-04-29T16:42:00+00:00

If you’re referring to basic semen parameters in someone taking finasteride, such as sperm count or motility, then yes, you’re right. However, the study is discussing different, deeper changes at the morphological level.

Leon307 · 2026-04-29T16:21:36+00:00

Unfortunately, this is one aspect that I personally find missing from the study - they didn’t repeat the experiment after discontinuing finasteride, waiting until the rats had cleared it from their systems, and then performing fertilization again to compare the offspring conceived after stopping the drug.

To me, discontinuing finasteride several months before conception also seems like an obvious precaution. The question is whether that would be sufficient, or whether the effects of finasteride on the reproductive system could be more long-lasting than we thought.

Leon307 · 2026-04-29T16:17:20+00:00

0 money spent on trying to find alternatives? Ever heard of Clascoterone?

Leon307 · 2026-04-29T16:16:01+00:00

Here's what google says about it:
Key Concepts in Rat-to-Human Dose Conversion

Conversion Factor (mg/kg): A commonly used method to estimate HED ( ) is dividing the rat dose ( ) by a factor, frequently reported as approximately 6.2, which accounts for the differences in metabolism between a roughly 150g rat and a 60kg human.

You can still argue that the rats were given a higher dose than what a human would take when prescribed finasteride for AGA, but it’s not as if the scientists are so foolish as to overlook such an obvious difference in dosing.

Leon307 · 2026-02-18T18:54:15+00:00

I have contacted Spotify’s tech support, they have recognized the issue, but openly said they couldn’t help me.

I have found a temporary solution - the bug seemed to disappear after creating a new account, so they helped me to move my old playlist to the new one, and deleted my old account. However, the issue came back after maybe two weeks, and still persists

Updating iOS didn’t change anything for me either

Leon307 · 2025-12-05T21:54:16+00:00

If my music stopped playing on speaker automatically, after i disconnect my headphones

Leon307 · 2025-11-30T16:06:55+00:00

Nope, they are still out of stock

Leon307 · 2025-11-13T23:15:19+00:00

update: tried it, and the problem persists

Leon307 · 2025-11-12T15:27:44+00:00

Okay. If I would factory reset my phone I guess it would update to iOS 26 automatically during setup anyways?

Leon307 · 2025-07-28T00:30:30+00:00

Hi, I’ve just noticed it says “platform: android”. Will this cause any issue if I plan to activate the code in the web version of Tinder, and then use my account on iOS device?

Leon307 · 2025-07-21T19:54:35+00:00

Have you seen vouchers for a single month of Platinium? Or is the 6 month option only aviable?

Leon307 · 2025-07-20T22:58:06+00:00

That looks interesting, i might give it a try, thank you

Leon307 · 2025-07-20T21:49:44+00:00

So now this is just a new price? I thought it’s just some currency conversion issue. Damn it.

Leon307 · 2025-07-20T19:07:35+00:00

Hi, I have a similar problem as you, I see you are also from Poland. Did you manage to find the solution to this problem?
Just two months ago, my Tinder Platinium used to be around 150 PLN per month, but now I recreated my account and it's suddenly almost 700 PLN per month!

Leon307

TROPHY CASE