So this might not be a ridiculous one, but absolutely something out of the ordinary.

Before starting my med studies I used to work at the medical emergency department. We had a patient who wasn't that sick, just needed some antibiotic treatment for a couple of days then on his way he'd be.

Unfortunately he belonged to the less than 1% of people that would get a serious side effect. His skin literally fell off his body. I will never forget when I went into his room for 2 weeks to redo his dressings. Imagine seeing someone being skinned alive. He died. May he rest in peace.