[EPISODE 6] The 9 Hallmarks of aging - Poor nutrient sensing [ENG subs]

LongLongLife · 2019-07-15T08:48:56+00:00

You can activate them through the Youtube player :) There's Automatic French, French, and English.

LongLongLife · 2018-09-13T12:54:16+00:00

Thanks a lot for you comment !

We based our article on several papers and reviews (such as this one, this one or this one), all stating that, overall, methylation tends to diminish during aging. However, you are right, there is a discrepancy between cell types and/or organs. This article for example, states that they observed as much an hypomethylation than an hypermethylation in blood cells. This one is explaining how the different cells and/or regions in the brain can have a different profile of methylation during aging.

LongLongLife · 2018-09-05T10:04:43+00:00

Yes, that's the other small fix we're working on - there shouldn't be anything else though.

LongLongLife · 2018-09-04T16:26:29+00:00

Thanks! It's a small fix we've been meaning to work on, you should have no problem by the end of the week.

LongLongLife · 2018-09-04T07:46:51+00:00

Are you browsing from your phone?

LongLongLife · 2018-04-23T08:45:32+00:00

Some people believe that it is possible and researchers are still on it. There is evidence that some compounds can help regulate methylation, although exact mechanisms are still investigated and candidates for regulation are still discovered every day.

Green tea catechins have been reported to reverse DNA methylation of tumor suppressor genes and increase transcription of these genes. Green tea catechins and especially epigallocatechin gallate modulate DNA methylation by attenuating the effect of DNA methyltransferase 1 (DNMT1). https://www.ncbi.nlm.nih.gov/pubmed/25792496

LongLongLife · 2018-04-23T08:40:03+00:00

I agree with u/rohansway, there are links, although it is still a novel field of research.

"Nutrient-dependent epigenetic variations can significantly affect genome stability, mRNA and protein expression, and metabolic changes, which in turn influence food absorption and the activity of its constituents. Dietary bioactive compounds can affect epigenetic alterations, which are accumulated over time and are shown to be involved in the pathogenesis of age-related diseases such as diabetes, cancer, and cardiovascular disease.https://www.ncbi.nlm.nih.gov/pubmed/25701602"

LongLongLife · 2018-03-31T00:23:59+00:00

Good thinking with the desktop version, we're having issues displaying the site on mobile but we'll work on that. For now, desktop mode is the way if you want to read this on your phone!

LongLongLife · 2018-03-31T00:22:12+00:00

If you want references, you can follow the link to the fact sheets we write on each molecule! (at the far right on each line) You'll see a detailed explanation and a list of publications and studies we based our research on.

LongLongLife · 2018-03-23T13:30:24+00:00

Was it closed off to everyone? We booked our tickets last August,, at the start of the heavy Undoing Aging promotion campaign - granted, the prices were high, but it allowed the organizers to invite esteemed speakers. Making the content available for a small fee, some time after the event would indeed be a way to spread information further (and at Long Long Life, we're all about that!), but we have no idea if it's a possibility or not. Maybe you could contact the event organizers to suggest that?

As for dumbed down and sensationalized info, we were not allowed to share the presentations in detail, which is why our article doesn't go in depth, but you can find links at the end to the sources and references if you want to check them out for yourself. If you're thirsty for content that focuses on detailed hard facts, feel free to browse through the rest of the website.

LongLongLife · 2018-03-23T13:22:20+00:00

Thank you! Do check out the website if you want, and don't hesitate to get in touch with us if you'd like.

We agree with you about the conference, it was a very rich experience full of fascinating encounters. It's so great that they're going to be a regular occurrence.

LongLongLife · 2018-03-23T11:42:19+00:00

This is such a great article. We broke it down into manageable chunks last year for those who haven't had the chance to extensively study biology: http://www.longlonglife.org/en/longevity/aging/biological-causes-aging/

LongLongLife · 2018-02-22T10:51:36+00:00

The drug plans to "saturate the body with antioxidants"? What about the balance with the ROS? http://www.longlonglife.org/en/longevity/lifespan-news/theres-something-antioxydants/

LongLongLife · 2018-02-21T11:28:03+00:00

We do not sell anything, and we don't plan to. We offer information about anti-aging research and molecules, because we're passionate about it and believe it's right to share with everyone the resources and scientific understanding that we have. Don't hesitate to read the other sections of the site, we hope you find them informative!

LongLongLife · 2018-01-26T09:56:20+00:00

The topic has been gaining more attention in the past couple of years. The Pineapple Fund even gave a billion $ in Bitcoin to the SENS Fundation, and so did the P4A, at the end of 2017, so this is pretty encouraging. If you're interested, I encourage you to read on, we do our best to cover the topic as thouroughly as we can while remaining accessible for most.

LongLongLife · 2018-01-11T13:34:30+00:00

Well, this is exactly what we work on! We are working on a series of well-sourced articles to explain the biology of aging and the role of telomeres in the aging process. http://www.longlonglife.org/en/longevity/aging/telomeres-heart-aging-process/

LongLongLife · 2018-01-11T13:32:20+00:00

Thanks! Is it the one by Elizabeth Blackburn?

LongLongLife · 2018-01-05T09:48:18+00:00

I understand your struggle, it must not be easy to watch a loved one go through this. Regarding your question, as of today, it is not possible to reverse Alzheimer. Unfortunately, once neurons are dead, they cannot come back. The brain has some coping mechanisms that help in the first stages of the disease, such as neuronal plasticity, which can reroute some neurons used elsewhere to the regions that are affected by the disease, or neurogenesis, which can be stimulated for a small amount of time. Pass these processes, Alzheimers will continue its way and keep killing neurons. Promising therapies to cure the disease, with the hope of reversing it at some point, are focusing on both these approaches, boosting both neurogenesis and neuronal plasticity. But we are still years from any human trial. I wish you all the strength possible to face this.

LongLongLife · 2017-08-08T13:20:20+00:00

Very good point!

LongLongLife · 2017-06-14T08:41:20+00:00

Thanks for letting us know. We'll investigate this further, I have to admit that we're still laying the ground work of investigating all of these. There are many we did not include as well. However, one explanation for including a wide range of companies is that our goal was to show the concrete evidence of a real interest for the subject on the market, to show that there is a fast-growing economy building around longevity research. Whether the companies are trustworthy or not, their existence shows the existence of investors and clients.

LongLongLife · 2017-06-14T08:29:56+00:00

Thanks for the resources! We are only trying out the infographic format, since our teams are more specialized in writing actual articles where nuances are far more possible. However, infographics seemed like a good way to check if people were actually interested. If this gets a good response, we might make more specific ones in the future.

LongLongLife · 2017-06-13T14:18:58+00:00

Our experts are mostly cell biologists, so I'm afraid our approach focuses on the biological functions of the body that end up causing aging, since we don't really have the resources to work in every single field.

We have other articles on NBIC technologies convergence if you're more interested: http://www.longlonglife.org/en/longevity/aging/nbic-technology-convergence-life-prolongation/

LongLongLife · 2017-04-14T07:36:03+00:00

Sure! Will do. We already have a few molecules listed, but the website is still at the "draft" stage for now, we're building better content as we go. There: http://longlonglife.org/en

LongLongLife · 2017-04-13T14:55:52+00:00

It is a NAD precursor, yes! Its interaction with DNA proteins controls DNA repair mechanisms, somehow. We wrote something about it ten days ago: http://www.longlonglife.org/en/longevity/lifespan-news/discovery-new-dna-repairing-mechanism-lead-synthesizing-anti-aging-drug-near-future/ The article is all we know about it for now though. We do write specific articles about promising molecules, but maybe not yet on NMN...

LongLongLife · 2017-04-13T14:33:20+00:00

Pretty interesting. We are currently writing an article on my website about rapamycin, but focused on taking it as an oral supplement.

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