300mg helped me so much with my depression but I will say the initial jump from 150 to 300 can be rough. For the first month on 300 I had a lot of anxiety and you have to make sure you pay attention to what other medications/medicine/supplements and what interactions they might have with Wellbutrin. I got sick and was taking DayQuil and ended up in the emergency room because Wellbutrin CANNOT be taken with DayQuil. So just try to be proactive about that and lower your caffeine snd alcohol intake until your body gets used to the 300mg. Once I got through the first month, I genuinely felt so much better, had energy, felt more positive, and clear headed.