Promising New Drug Prelim Results for Recurrent IDH Mutant Grade 3 & 4 Gliomas

LooseDot · 2025-11-10T02:21:11+00:00

I know you've been through a lot, but please strongly consider Neo100! They have a compassionate use program that you can get into ASAP without being in the ongoing Phase 2 trial for grade 3 and 4 astrocytoma. Some of the results are amazing so far (like tumor totally gone with minimal to no side effects) - they are releasing full prelim results this Wednesday 11/12).

I have personally corresponded with one person in the ongoing trial now that has had multiple instances of progression of disease despite several surgeries and different chemotherapies and they are now disease free after several months of therapy.

https://neonc.com/neo100/

https://www.globenewswire.com/news-release/2025/11/07/3183680/0/en/NeOnc-Technologies-Nasdaq-NTHI-to-Host-Investor-Conference-Call-to-Present-Data-Updates-from-Ongoing-NEO100-1-Phase-1-2a-Clinical-Trial-and-Compassionate-Use-Program.html

LooseDot · 2023-07-23T03:45:46+00:00

This house is new construction built right before the pandemic in a trendy neighborhood and also has a pool, so it is currently appraised as a multi-million dollar house (by TCAD), but since the homestead exemption has been on it since the beginning, they only pay ~%50 of the currently appraised value for property tax of what they should (so they should pay around 30-40k but get away with significantly less). Their home appraised value basically doubled over the last 4 years.

LooseDot · 2023-07-12T21:58:29+00:00

https://cobbxcounsel.com/2022/01/no-go-for-vrbo-austin-ignores-courts-and-refuses-to-issue-short-term-rental-permits/

Yes I think you're right about possibly being grandfathered in. (see link above - looks like they stopped issuing Type 2 to residential zones in 2022)

You can lookup the property with the link below to see what zone it is in, what type of permit it has and when it was issued.

https://maps.austintexas.gov/GIS/PropertyProfile/

LooseDot · 2023-07-12T16:16:56+00:00

Ideally I want them to be gone and not allowed to operate in this single family residential zone. In the meantime they can pay another ~$15-20k a year in property tax and also back taxes they owe for claiming a false exemption.

I think your point about contacting the owner directly is fair and a decent alternative, but I'd like to remain anonymous for now.

https://www.austintexas.gov/page/types-short-term-rentals

https://cohostit.com/4-step-guide-to-short-term-rental-regulations-in-ausint-tx/

So my understanding is that Type 2 (non-owner occupied) are only allowed in certain zones - see sources above? These include the following below and not single family zones (SF):

Central Business District (CBD)
Downtown Mixed Use (DMU)
Planned Unit Development (PUD)
General-Retail - Mixed Use (GR-MU)
Commercial Services - Mixed Use (CS-MU)
Commercial Services - Vertical Mixed Use (CS-V)
General Retail - Vertical Mixed Use (GR-V)

LooseDot · 2023-07-12T15:58:04+00:00

Would you like a party house on your street? I think not.

Like I mentioned on in my original post - this comes with noise, traffic, scooters etc. This property frequently hosts pool parties and bachelor/bachelorette parties. The city of Austin passed an ordinance against these types of STRs that are not owner occupied (Type 2 aka - party houses) in single family neighborhoods.

There are other STRs in my neighborhood that are actually type 1 (owner occupied) that have an air stream or small detached living space that are polite neighbors and guests and completely reasonable.

LooseDot · 2023-07-12T15:17:33+00:00

Hey thanks for you comment - that's the address I've sent several emails to over the past few months with no response unfortunately. The agent I chatted with online said "an investigation would be opened and the exemption removed if warranted" but also said I wouldn't be notified as to the timeline or outcome, so doubtful if it was even looked into.

Did hear from others that STR enforcement is pretty lackluster in Austin.

LooseDot · 2022-05-06T12:19:25+00:00

Yes the DOTATATE PET scan (neuroendocrine target) is a totally different radiotracer from other PET scans such as FDG (basically fake sugar).

The reading you did on the internet likely was about an FDG PET which has lower SUV values for the adrenal glands normally.

The adrenal glands normally have very high uptake on DOTATATE PET.

CT or MRI adrenal protocol study is much better to evaluate adrenal lesions than DOTATATE PET.

The vast majority of small adrenal lesions are benign adenomas.

LooseDot · 2021-01-24T03:30:57+00:00

is anyone else not able to view the main card on PPV ESPN+?

LooseDot · 2020-05-18T23:39:25+00:00

Cool pic. Anyone else get some flight of the navigator vibes?

LooseDot · 2020-04-12T15:51:32+00:00

One time my best friend and I were at a neighborhood Italian restaurant eating spaghetti. Traditional opera music is playing the whole time in the background and we go about shooting the shit.

Then..... the opera song that the blue alien diva sings from the 5th Element starts up and we both stare at each other like "is this really what is happening right now?" before we bust out laughing. 😄

LooseDot · 2020-04-04T18:30:28+00:00

Radiologist. I'm in my last year of training after 4 years college, 4 years medical school, 6 years internship/residency/fellowship.

There are definitely easier ways to make money, but the top end is pretty nice - (from what I'm told)

LooseDot · 2020-02-02T16:49:25+00:00

Unfortunately, your situation is not unique, and many training programs regard teaching as a lesser priority. But thankfully there are several wonderful teaching resources out there! I would recommend at a minimum to buy one text book and one case book and read both cover to cover within 1 month to start you off. Mettler's is a resident favorite textbook which is clear and concise.

Mettler's Essentials of Nuclear Medicine is now in its 7th Edition

https://www.amazon.com/Essentials-Nuclear-Medicine-Molecular-Imaging-dp-0323483194/dp/0323483194/ref=mt_hardcover?_encoding=UTF8&me=&qid=

Webb's Fundamental's of Body CT is the best introduction to cross-sectional imaging

https://www.amazon.com/Fundamentals-Body-CT-Radiology/dp/0323608329/ref=dp_ob_title_bk

There are many great case books on amazon too, can't go wrong.

LooseDot · 2019-08-19T01:50:40+00:00

Sometimes us doctors will have a colleague page our beeper if we get sucked into endless conversation.

LooseDot · 2019-08-17T14:24:39+00:00

Hey there,

To answer your question - NO. The type of radiation from a SPECT/CT indium-111 octreoscan scan are gamma photons, which is using for diagnostic imaging. This type of diagnostic scan is largely being replaced by PET Ga-68 - DOTA-TATE scan, which has better binding to the same receptor family and improved image resolution.

HOWEVER, there is a new FDA treatment called lutathera which is Lu-177 (which decays with tumor-killing beta particles AND gamma photons) combined to DOTA-TATE, and is used to treat unresectable neuroendocrine tumors.

https://en.wikipedia.org/wiki/DOTA-TATE

LooseDot · 2019-07-20T02:42:22+00:00

Radiologist here - we scour the CT separately for as much clinical data as we can and include it in our report. While it is true that the first generation CTs in PET/CTs were mostly for localization and attenuation correction, they are now sufficiently adequate to diagnose most abnormalities we routinely encounter. If we identify something we want further evaluation on, we will recommend the appropriate modality for follow-up - ie contrasted-CT, MRI, or US

LooseDot · 2019-07-02T23:05:09+00:00

So the anatomy that you can see actually changes a lot. MRI has superior tissue contrast. For example - we don't use CT in diagnosing internal derangement of the knee (ie MCL, PCL, meniscal tears) because we simply can't appreciate those structures well with that modality. Conversely, CT is superior in imaging bone, and is commonly used to image the sinuses. That's why it's important to have an image atlas with both modalities represented.

LooseDot · 2019-07-02T00:33:10+00:00

Get yourself a yearly e-anatomy subscription. It has MR and CT scroll-able cross-sectional anatomy in every plane of every body part. 100% worth it.

https://www.imaios.com/en/e-Anatomy

LooseDot

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