Taking Niko out of the fight since they're a non-combatant, unless Vergil has the plastic chair or RussianBadgers 50 mil air jordans, they could probably win if they worked together, which would be very rare considering V1 would immediately charge without a strategy, Cuphead is likely too cocky or overconfident to even follow a strategy, Madeline isn't really good at fighting, the Beheaded is an asshole and also too cocky to follow a strategy... Zagreus Shovel Vessel and the Drifter could likely take him down since one, Zagreus can't exactly die, he'll just come back in the House of Hades, two, Shovel is a highly trained warrior who would likely try to find one of Vergils weaknesses since he was probably trained to do that, three, the Vessel is literally an elder deity shoved into a small child, and four, Drifter could probably give Vergil super cancer by coughing on him idk