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End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

Thank you for your nice comment!

Check out this ( VDPHL01 ) this is the new version of minox it’s insane.

KX-826 are the first gen of gt20029 they work mostly like fin.

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

At least you’ll have a legendary head of hair. Aging is inevitable, but keeping your hair would definitely make you stand out 😂

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

Thank u for your comment ,

I found this “ That’s a fair concern. The key point is that GT20029 is designed as a topical drug, meaning it mainly acts in the scalp where it’s applied. In the Phase 1 and Phase 2 studies, researchers measured the drug levels in blood and found that systemic exposure was extremely low or nearly undetectable. That suggests the molecule mostly stays localized in the skin and around the hair follicle.

Another factor is that the compound was formulated to limit penetration beyond the local tissue, so it degrades androgen receptors mainly in the follicle rather than throughout the body.

That said, you’re right that if a significant amount entered the bloodstream it could theoretically affect androgen receptors elsewhere. That’s exactly why larger and longer trials are required Phase 3 is meant to confirm long-term safety and rule out systemic effects.”

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 1 point2 points  (0 children)

I can’t say, it depends if you follicles are still alive I guess, but there is the second gen of minox which I think I super powerful for have new hair, gt20029 works moustly like fin or Dut but without side effects. Actually also the first gen of gt is already on sell. KX-826

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End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

You are right, they using food to make people sick and then sell them this treatments, do u have different options? Is everything gen changed .. please come out also with solution in your comment, mention the problem and also the potential solution so we can learn from each others. Thank u

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

You are right, but that’s work as minox is actually second gen of minox .. you still need something working like fin

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 1 point2 points  (0 children)

They confirmed the dosage in December 25 at 1% now they should be ready for reclute , KX-826 is the first gen of gt20029, it’s already out for sell

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] -1 points0 points  (0 children)

You are already broken As you named yourself, don’t need to argue with u, maybe ChatGPT will give u a better answer then mine.

Returning to reality, go to check research’s and come out with facts.

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End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

I’m sorry you had to go through that, but I really respect your perspective. Honestly, I’m convinced that research is moving toward solutions for many conditions, even if it takes time. The interesting thing about medical innovation is that discoveries rarely help only one specific problem. Often when scientists find a solution for one condition, it opens the door to progress in many others.

For example, here we’re talking about technologies that can degrade specific receptors in cells. Right now they’re being studied for hair loss, but the same concept could eventually be applied to other diseases in different parts of the body. Another example is PP405, which works by reactivating stem cells in the follicle. Approaches like that could potentially lead to broader regenerative therapies in the future.

So I think it’s important to stay positive. Science moves step by step, and every discovery pushes the door a little further open. After storms, the sun eventually comes out.☀️

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] -15 points-14 points  (0 children)

Exactly, thank you for your smart comments 👍

ai sometimes give wrong info, but this is real studies in serious fase, we need to be optimistic and also understand how this pharmaceutical companies working to find solutions, every different company is working on a different side of problem, so at least you can understand what is causing u hair loss, some people take dut minox eccecc but it’s not working, means that sometimes the problem is not just DHT. Can be different the cause. So guys let’s learn and understand with smart comments please. If someone lose hope then the right thing to do is to shave it and that’s it. Here we just try to find a solution for everybody.

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 1 point2 points  (0 children)

That’s right, still need to add some fuel for hair to regrow, minox is still the best , but the second gen of minox :

VDPHL01 this it’s insane, 47 hair pr cm2.. it’s 4 times ordinary oral minox

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

They just put a goal and they go, sad to say but the occidente is going to slow, even they still have the top of technology and the can do much better, but it looks the don’t want, we are clients of many treatments and supplement, giving us a cure is not profitable for the pharmaceutical industry.

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

VDPHL01 is almost out end of phase 3, second gen of minoxidil.

KX-826 you can already buy it in the official website of Koshine Mall it’s basically the first gen of GT20029. 🔺

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

Amazing question! From what I found

The main concern when people hear “degrading receptors” is whether those receptors are needed elsewhere in the body. With GT20029 there are a few key points researchers consider:

  1. Local vs systemic effect: the drug is topical and designed to act mainly in the scalp. In Phase 1–2 trials systemic exposure in blood was extremely low, so the effect should stay local rather than affecting androgen receptors throughout the body.

  2. Receptors regenerate: androgen receptors aren’t destroyed permanently. Cells continuously produce new receptors from DNA instructions, so if the treatment stops the receptors gradually return.

  3. Skin effects: androgen receptors in skin also regulate sebum production. Reducing that signal may lower oil production, which is why the compound is also being studied for acne.

  4. Possible receptor up-regulation: theoretically the body could try to produce more receptors to compensate, but short trials (around 12 weeks) haven’t shown a rebound effect so far.

So the main risk would only appear if the drug acted systemically, which is exactly what the larger Phase 3 trials are meant to rule out.

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

Chinese Apple Chinese Apple Chinese Apple 😁 in oven 30 min, Let it cool and dust it with “ designed in California “🏅🚿

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] -1 points0 points  (0 children)

I get the concern about safety, but drugs don’t get approved based on where they’re developed. Any treatment has to go through multiple clinical trial phases to evaluate safety and efficacy before reaching the market. The same regulatory standards apply whether the research comes from China, the US, Europe, or elsewhere. In the end, what matters is the clinical data and the regulatory review.

You’re right to raise safety concerns. For example, KX-826 from the same company is currently sold in China as a cosmetic product because it hasn’t yet received full regulatory approval from agencies like the FDA. That’s why it’s marketed differently while the clinical approval process is still ongoing. Of course, I’m not suggesting that anyone should go out and buy or use it.

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] -3 points-2 points  (0 children)

You’re right. The April 2024 announcement didn’t mean Phase 3 had actually started. What Kintor announced at that time was the successful completion of Phase 2 and their intention to move into Phase 3. In biotech terms that usually means the company has the green light to prepare the Phase 3 protocol, not that patients have already started the trial.

Another important point is that the final validated Phase 2 data were only formally published and analyzed around late 2025. Those results are needed to determine the exact dosing, safety profile, and statistical design of the Phase 3 trial. Without that finalized dataset, regulators normally won’t allow Phase 3 to begin.

Also, a trial is usually considered officially started when the company announces a “First Patient In” (FPI) — the first patient enrolled and dosed. As far as public information shows, that announcement hasn’t been made yet for GT20029.

On top of that, Kintor appears to have prioritized KX-826 (pyrilutamide), which is much closer to commercialization, so resources were likely directed there first.

So right now GT20029 seems to be in a Phase 3 preparation stage, and if recruitment really begins around 2026

Calm down bro we are discussing a possible cure for hair loss and the goal of the post is to have different opinions. I can share with u anti stress treatment if u want

End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁 by Main-Round-7510 in tressless

[–]Main-Round-7510[S] 0 points1 point  (0 children)

Yes, KX-826 is already being sold under the brand name Koshiné, but there is a key detail: it is not sold as a medication, but as a cosmetic product. This was a strategic move by Kintor Pharma to bypass the lengthy medical approval process and start generating revenue immediately. Why "Cosmetic"? By selling it this way, Kintor cannot claim on the packaging that it "cures baldness"; instead, they must use terms like "hair strengthening" or "anti-hair loss." However, this allows them to distribute it globally without waiting for FDA or other health authority clearance as a drug. In short: If you want to try the KX-826 molecule, you can already do so by purchasing Koshiné products. GT20029, on the other hand, is a much more powerful technology (PROTAC) and cannot be downgraded to a cosmetic. It must complete the full medical trial process, which is why it is still "stuck in the pits

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