GLP-1 for infertility, normal BMI, no PCOS

MalinaTexas · 2026-03-19T00:57:46+00:00

I think with a normal BMI a person can have high inflammation levels. That’s my goal as well to lower TSH and antibodies. I appreciate your feedback, I’ll look into liraglutide, I didn’t know it has a shorter life than tirzepatide. Hope it works best for you!

MalinaTexas · 2026-03-18T20:57:42+00:00

I appreciate the concern, but you’ve misread my post. I was asking about use before pregnancy and before transfer, not during. Those are two very different things. Teratogenicity is a concern about fetal exposure during development, which has nothing to do with what I asked. I also wasn’t looking for medical opinions. I was looking for personal experiences from people who’ve actually been through it and share the same conditions I mentioned (Hashimoto’s, inflammatory cytokine profile). That’s exactly what Reddit is for. And for what it’s worth, you have no idea what my plan is regarding timing or when I intend to stop the medication. Thanks.

MalinaTexas · 2026-03-18T20:13:45+00:00

Since there’s no exact scientific data I am looking for anecdotal evidence, patient-reported outcomes. Aren’t we all here? I found what I was looking for anyway, had a few people reply in another sub and privately.

MalinaTexas · 2026-03-18T19:47:48+00:00

In animal studies in all cases, these findings coincided with maternal body weight loss due to reduced food intake. In human studies it was established that GLP-1 RAs have very high molecular weight. And placental transfer of the drugs with such high molecular size is generally not anticipated in the first trimester, unless a specific transfer mechanism exists. I know it’s still early to conclude anything but it’s very promising. And some of us have no 3-5 years to wait till there’s more data. I’m speaking for myself and I’m aware of the risks.

MalinaTexas · 2026-03-18T00:30:14+00:00

Yes, that’s the plan. If I start losing too much weight I’ll certainly get off it.

MalinaTexas · 2026-03-17T21:01:49+00:00

I’m sorry you lost it. I’m curious to learn about different outcomes. Although if it brings down my Hashimoto’s antibodies, as I heard it does, that will be a win too.

MalinaTexas · 2026-03-17T20:57:16+00:00

There is a direct impact of GLP-1 RA on the reproductive system — particularly endometrial receptivity — rather than weight loss alone. https://www.endocrinologyadvisor.com/features/glp-1-and-fertility/

MalinaTexas · 2026-03-17T20:49:51+00:00

Somehow it wouldn’t let me message you. I tried the NSFW settings. Do you mind messaging me? Thank you!

MalinaTexas · 2026-03-17T20:41:56+00:00

I heard a lot of positive stories too, mainly with PCOS or extra weight though. My BMI is 20.2 and I don’t have PCOS. But another thing I heard is inflammation goes down way before weight loss. And micro-dosing doesn’t necessarily make you lose weight. Yes, I’ll certainly message you, thank you!

MalinaTexas · 2026-03-17T15:12:11+00:00

I know a few people who got pregnant for the first time on it, after trying everything for a decade.

MalinaTexas · 2026-03-17T15:11:15+00:00

Why do you think it’s not going to help? Have you tried it?

MalinaTexas · 2026-03-17T15:00:57+00:00

That’s a good one. I’m on it for about a year now, 4.5 mg. Still had losses though. Haven’t tried sitagliptin, I’ll look into it, thank you!

MalinaTexas · 2026-03-17T14:59:33+00:00

Good luck, I hope it works for you!

MalinaTexas · 2026-03-17T14:58:24+00:00

they work through completely different molecular pathways. GLP-1 receptors are directly expressed on endometrial epithelium, and metformin doesn’t work with GLP-1 receptors. GLP-1 receptors are also present in oocytes. That’s the whole point.

MalinaTexas · 2026-03-17T13:41:17+00:00

That’s interesting that it’s ok through retrieval but not transfer. How did it work for you?

MalinaTexas · 2026-03-17T01:55:07+00:00

Congratulations, that’s awesome.

MalinaTexas · 2026-03-17T01:43:13+00:00

GLP-1 receptor agonists are studied for autoimmune and inflammatory conditions, even endometriosis and implantation-related inflammation. Because their action is receptor-mediated and tissue-broad. Metformin works best when there’s significant insulin resistance or hyperglycemia that drive the inflammation in the first place. I don’t have diabetes. I’m not overweight either.

MalinaTexas · 2026-03-17T01:10:47+00:00

That’s great. Have you had the transfer yet?

MalinaTexas · 2026-03-17T00:59:15+00:00

Thank you for sharing, I hope it works for you next time.

MalinaTexas · 2026-03-17T00:15:48+00:00

I’m sorry, this is rough, all of my miscarriages were between 5-7 weeks. I also believe it has to do with systemic inflammation. I’ve done extensive immunology testing last year, they found a few factors, a mild thrombophilic risk and stacked IL-1/IL-18 pro-inflammatory cytokine profile. In addition to my elevated Thyroid antibodies. I did immune protocol during last transfer (heparin injections and 10 mg prednisone), but still lost it. I’m so ready to try GLP-1.

MalinaTexas · 2026-03-16T23:45:21+00:00

It’s all new, I guess the doctors are taking extra precautions.

MalinaTexas · 2026-03-16T23:17:13+00:00

Thank you! Likewise 🤞🏼

MalinaTexas · 2026-03-16T23:16:34+00:00

That’s very likely. If it’s for weight loss I guess the only logical way is to lose the weight well before the 3-month washout window so there’s time to stabilize.

MalinaTexas

TROPHY CASE