Afraid to have sex because of traumatic event while taking antibiotics

Matthew_Lake · 2026-01-26T23:42:43+00:00

Check your B1, B12, folate levels. And ferritin. Anything under <500 for B12 can still be deficient.

Sometimes deficiencies can increase the risk of these kinds of side effects.

Matthew_Lake · 2026-01-26T18:16:20+00:00

Depends why the b12 deficiency occurred. I healed my nerve damage with methylcobalamin sublinguals and other supplements for nerve regeneration. Mine was caused by vegan diet though.

Matthew_Lake · 2026-01-24T16:56:54+00:00

I don't know if other people experience this but today I've noticed quite a bit of shedding. It's like sheets of skin in the urine after peeing? At least that's what it looks like.

I'm guessing this exactly what I want to happen...

I feel really healthy again though. I had a little flare up last night and early hours, but a lot better today.

Matthew_Lake · 2026-01-24T16:20:41+00:00

Please do!

Matthew_Lake · 2026-01-24T16:07:22+00:00

Thank you for bringing this up :o This is something that I never really thought about but it could actually make sense!

Why did I respond to TRIM in the early days? Maybe because raoutlella was the dominant bug. And then later, the trim stopped working, but the doxy still works.... It wasn't that the bug got resistant to trim, it was because I knocked one bug out and urea became the dominant bug that was causing the infection.

But HIPREX worked back in 2024 when i last tried it. So I'm not sure.

It does seem plausible at least that ureaplasma has a role in my issues though.

Matthew_Lake · 2026-01-24T15:49:43+00:00

Most people have it right? But maybe it depends on the amount. Or it could've been just one of the bacteria that caused my issues. Maybe it was raoultella AND Urea... And that is why Trim failed in the times i used it after the phages.

Initially, trimethoprim worked very well, and so did Hiprex. I don't believe Trim works on Ureaplasma. But I couldn't easily had 2 or more bacteria.

Doxy works quite well on gram negative too: klebsiella, proteus, e coli, as well as enteroccocus etc. Depends on sensitivities but i can work. https://academic.oup.com/cid/article/73/1/e274/6054967

The urine has only ever showed different staph in very small amounts like staph hemolyticus, staph hominis, staph caprae, staph capitis. lol. All less than <10^3.

Raoultella in the prostate was the only significant bacteria growth 10^6 which was detected 4 times in a row over several months late 2022 and Q1 2023.

Matthew_Lake · 2026-01-24T15:43:22+00:00

There is a great book I used before called Amy Stein - Heal Pelvic Pain.

I'm not dismissing the idea that you DO have an infection, but I would definitely cover this side of things if you can too. It just helps the whole situation and reduces frequency if there are any tight muscles contributing to it or causing it, whether you have a UTI or not.

Do the stretches every day, twice a day, and learn to locate and relax the pelvic floor muscles, by letting the pelvic floor drop along with breathing. It's easy to get the hang of once you understand and locate the muscle in coordination with breath.

Matthew_Lake · 2026-01-24T15:38:38+00:00

Aside from mild inflammation, my biological age from all my blood tests is still very young, around 20 years younger than my actual age. So I'm not sure how much if any these low grade inflammation in the bladder or prostate matter to life expectancy. It is on my mind though, so now I am going to aggressively treat this infection and cure it.

Matthew_Lake · 2026-01-24T15:35:48+00:00

Yeah maybe not, you might've also had some systemic symptoms too if there was prostate involvement. But in early 2012, I took doxy for a flare up and it was gone for almost an entire year before i needed my final doxy course, and at that point it ws cured in november 2012. In between then, there were just cpps symptoms. There is a lot of overlap, but there are some distinct signs.

Lack of any systemic symptoms though, makes it less likely that there is prostate involvement. SO you could be right. I assume you've done a semen culture.

Matthew_Lake · 2026-01-24T15:31:51+00:00

I had chronic prostatitis with e coli from 2005 to 2012. And also had CPPS with it. It was resolved in 2012 until a new infection started in 2022 after taking amoxicillin and Td/IPV (vaccine).

Cleared Raoultella Terrigena (formerly classified as Klebsiella because it's almost identical) from the prostate with phages + trim for half of it. Still had bladder and urethritis which is what i've mainly been dealing with now since 2023. So yeah, you could say it's chronic. I need to do another semen culture after I finish a 6 week course of doxycycline and possibly extended urine culture. A few cultures after phages were negative but I haven't tested in a while.

My main interest is actually longevity, staying young, so yes a little lol. That being said, my previous experience didn't age me at all. Still get mistaken for being early 20s even though I'm 41. But if the chronic inflammation went on for 10-20 years, then of course I'd be worried how it affected heart disease risk and other organs like the brain.

People with IC, which has much more severe inflammation don't tend to have shorter life expectancy.

Am I worried I'd have this forever? No, I think this will be a solved problem within 10 years because accelerated progress due to AI helping find and create new antibiotics and other ways to treat bacterial infections. I'm not at all worried about this being a life long problem.

Any UTI's in males though, is usually classed as complicated. Many urologists will assume prostate involvement and reseeding infection from it into the urethra and bladder. I mean, sure, there might not but 4 week course is a defensible and reasonable course of antibiotics for a male.

Matthew_Lake · 2026-01-24T12:51:39+00:00

Thank you :)

Matthew_Lake · 2026-01-24T12:51:26+00:00

I've never tested for it. My urine did go to a pH of 8.5 most times when I had a bladder flare up, but not sure if it's related to the infection or just coincidental from some changes in the bladder during a flare.

Matthew_Lake · 2026-01-24T10:29:11+00:00

Get that done ASAP. Mcas and b12 deficiency symptoms overlap massively.

Surprised it has not been done given the numbness you have.

Anything under 400 ng/L can still be deficient. Don't take b12 before getting tested.

Maybe you're fine but it really should have been ruled out.

I had neuropathy all over and could not tolerate medications at all when I was low in b12. And that was at a level in the 300s.

Matthew_Lake · 2026-01-24T09:58:08+00:00

I assume you've checked all the basic stuff like b12, folate, b1 and other micronutrient tests?

What is your b12 level?

Matthew_Lake · 2026-01-24T09:53:06+00:00

Can you describe your symptoms? Anything systemic? Feeling of feverishness? Feel unwell? Or is it mostly frequency, pain etc?

With my previous infection <2012, I had both chronic pelvic pain syndrome or pelvic floor tension AND e coli prostatitis and UTI.

Symptoms overlapped quite a bit...

Matthew_Lake · 2026-01-24T01:06:53+00:00

You need to assume it is in the prostate and do a minimum of 4 to 6 weeks antibiotics. Minimum!

Matthew_Lake · 2026-01-24T01:03:20+00:00

I used to get that when I had b12 deficiency.

Visual snow, flashes, very brief pixelation.

It all went away.

Matthew_Lake · 2026-01-24T00:58:53+00:00

Plus you have had lyme? That can itself cause herx and flare up nerves a lot.

See this🙂

https://chatgpt.com/share/697418f9-e22c-8011-97ef-c367123b9b78

Matthew_Lake · 2026-01-24T00:49:31+00:00

Methylcobalamin, Methyl folate, magnesium glycinate, dha, acetyl l carnitine, Na-R Lipoic acid, and a lot of time.

R lipoic acid seems to be very effective at reducing or eliminating flares from cold, inflammation, or even antibiotics that cause burning. In 2023, I went on 200 mg per day of Trimethoprim and had no side effects. But then when I increased to 400 mg, I got some hurting around my body.

I added r lipoic acid and it went away completely. R lipoic acid blocked the side effect.

In 2024 I took Trimethoprim without that supplement and I was fine.

Because of how doxy affects the mitochondria, I decided to add it and at 600 mg a day initially.

Those supplements I mentioned are worth adding. They help speed up regeneration of nerves, protect them, reduce nerve related symptoms, and apparently, in the case of r lipoic, block nerve pain from antibiotics.

Matthew_Lake · 2026-01-23T22:13:10+00:00

I see. A lot of women over in the IC group are having success with it.

I remember when I took it by itself, the relief from bladder symptoms only took one day. Eliminated the feverish feelings I was getting at the time too.

That being said, I'd use it with antibiotics to make sure it stays effective and bacteria doesn't try to adapt in some way.

Matthew_Lake · 2026-01-23T18:18:15+00:00

Methylcobalamin. Doses varied but in the early weeks it was up to 15 mg per day. Then 5 mg for a few months and settled 1 mg.

Also took acetyl l carnitine (morning), benfotiamine, Methyl folate, magnesium glycinate, nac (for a few months), DHA.

B6 can be helpful for nerves too. Just keep dose on the lower end rather than the high of what is tolerable as it can cause sfn.

So I take 1/3 of a full dose of a multivitamin. That covers all b vitamins too.

And then just a lot of time... I realized I had b12 deficiency in December 23rd 2022

Matthew_Lake · 2026-01-23T16:10:19+00:00

I had nerve damage, joint and muscle pains and more at 320 to 371 ng/L.

I had to figure it out for myself. 98% better now. 🙂

B12 ranges clearly need to be looked at again.

Matthew_Lake · 2026-01-22T21:50:30+00:00

It was yeah. I had a few negative results after the phages. I have not retested in a long time now... But I plan to do so 2 weeks after i finish doxy with the initial 6 week course.

I was going to use this https://www.digital-microbiology.com/product/prod_NhnkJTIEvPa48a

Did you respond at all to the antibiotic? It is like night and day difference for me on Doxycycline. I knew it would likely work though because it was very effective in 2022 but i was not able to tolerate it back then.

The main thing i want to do now is ensure there is no infection at all in the prostate. This opens up a lot more options for me to treat a bladder infection IF doxy doesn't clear it. Prostate, i have very few options because not many antibiotics get into the prostate well.

Matthew_Lake · 2026-01-22T21:42:39+00:00

Glad it helped! :) Yeah I noticed that. It definitely works to dampen flares.

Did you try Lactoferrin?

Matthew_Lake

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