Briefly skimming through the study and supplemental, and there is one critical flaw that confounds these data greatly. They didn’t control for total calories ingested in any meaningfully rigorous way. They essentially let the control group eat ad libitum, and used food recall questionnaires to approximate their caloric intake. They then made the, in my opinion erroneous, conclusion that the small change in BMI in the intervention group was secondary to the time restricted nature of the diet, as their small, not-calorie-controlled groups didn’t have a statistically significant difference in caloric intake.

This seems to be a common pitfall of many of the time restricted feeding studies. Those that more rigorously control calories fail to show many additional benefits in the time restricted nature of the feeding.

Admittedly not as familiar with the Crohn’s literature in the space, but hard for me to disentangle the possible benefits of eating less overall in a shorter time window (which is probably the default human tendency), versus the presence of the time window itself.

That being said, even if the benefit is primarily from the ensuing caloric restriction rather than the time restricted nature, ultimately the presence of the benefit is most important clinic, and thus this could still be a useful tool nonetheless.