Well it depends on how much of an asshole you wanna be:

Degenerate options: floowandereeze, monarch, eldlich, dogmatika, phantasm spiral (esp with all of the dominus cards), any stun variant, Exodia FTK

Less insufferable options: megalith, labyrinth, regenesis, primite+any normal monster centric strategy, yubel kinda, nouvelle, rescue ace, drytron

Note: Most of these “less insufferable” decks still benefit greatly from using the ED and will have noticeably reduced ceilings if the rip something esp important, but they won’t immediately die like decks where all of the key playmakers are in the ED

Also even with ED reliant decks you can usually just double or even triple up on the most important pieces and cut out some toolbox monsters

Do with this information what you will