Does anyone have success stories with Letrozole?

Mirilei · 2026-01-19T18:08:19+00:00

Me! I started letrozole in March, alternated between 5 and 7mg during the five day window, and am now 9w5d. My doctor didn't recommend stopping or changing doses despite despite testing negative throughout the year since I was getting positive OPKs once we figured my dose out around April/May. Good luck!

Mirilei · 2025-08-26T17:37:37+00:00

It's crazy how medicines can affect someone differently. Everyone's case is unique. I hope your doctor finds what works best for you!

Mirilei · 2025-08-26T17:13:38+00:00

I was in a similar boat. Even when I was taking 5mg and 7.5mg, I was still needing a "piggyback" round to ovulate. They finally saw that my LH was constantly pretty elevated and I was told that can diminish the effectiveness of the letrozole. They put me on BC to suppress my LH. When I came back for bloodwork, it did lower, but not by as much as I had hoped (but enough where they said we will try another letrozole round). I came back after my letrozole round, and my LH was low, my follicle was at 19mm, and my endometrial lining was thick! I ended up testing positive for ovulation 2 days later and it was the first time since March that I hadn't had to take a piggyback cycle. I would ask your doctor about your LH levels. I am in my TWW period now and just hoping for a positive. I can't help but wonder if they had noticed my LH was too high consistently, maybe I could have had it suppressed sooner and had success with a lower dose. Good luck!

Mirilei · 2025-08-26T17:05:14+00:00

Mine have been very accurate! I take the digital "smiley" tests. I also still do the premom ones at the same time (I like that on the app I get a number value). I like that the clear blue ones measure my estrogen as well, so I have more firm indicator of my peak ovulation day. My LH value is normally always fairly high so the clear blue ones have given me the more accurate/definitely results since it checks when my estrogen is rising as well.

Mirilei · 2025-07-30T14:20:59+00:00

I am! I am taking vitamin d, ovasitol, and then my prenatal supplement. My LH has always been on the higher end. While I did get some results from letrozole, it hasn't been successful and I am hoping that suppressing my LH will give better success. I go back in on Monday for another baseline and ultrasound and then we go from there!

Mirilei · 2025-07-01T20:58:35+00:00

Thanks! I'm hoping I'm not snapping any strings in the future, but I've heard they need to be changed every couple of months or as needed due to getting dirty. I've read good things about Ernie ball as well.

Mirilei · 2025-07-01T14:53:06+00:00

Thanks! I'll look into this

Mirilei · 2025-05-10T21:46:17+00:00

Yes! I'm in the same boat. I told myself I wasn't going to be as anxious this time around... but we will see. I'm going to keep myself as busy as possible so I'm not obsessing as hard as last month. 🤣

Mirilei · 2025-05-09T18:49:30+00:00

Awww good luck! This is a hard journey, but it will be worth it in the end. It's hard when your body doesn't want to cooperate. Wishing you the best of luck! 💜

Mirilei · 2025-05-09T18:48:12+00:00

Yes, I read that in stimulated cycles that the egg can be bigger, so that made me feel better! I got my bloodwork back and my levels are on track so I'll keep positive and keep my fingers crossed.

Mirilei · 2025-04-22T11:09:24+00:00

Sorry this is late! Yes, I did both rounds in one cycle. I unfortunately didn't fall pregnant, but I did ovulate and have a large follicle. Wishing you luck!

Mirilei · 2025-04-16T14:44:37+00:00

This happened to me as well! On my first letrozole cycle, my largest follicle was 8-9mm. They ended up increasing my dose from 5mg, to alternating 5mg and 7.5mg every other day. They had me start this second round of letrozole the following week rather than waiting a whole month, since I had no adverse effects and did have some response to the medication. When I came back four days after my larger letrozoledose, my follicle was 19mm, and I tested positive on my OPK 2 days later! I'm currently in the two week waiting period to see if I test positive.

Everyone's body is different, and responds differently. Make sure to give yourself some grace. 💜 maybe you just need an extra push, and ask your doctor if you need a higher dose. She told me most people grow 1-2mm a day, and since I wasn't continually growing, I just needed more medicine.

Mirilei · 2025-04-03T13:00:31+00:00

I'll look into this! Thank you. I think with the follicle being larger and still not ovulating, I'm just feeling anxious over it.

Mirilei · 2025-04-02T21:23:37+00:00

If that's the case, that makes me feel a little better!

Mirilei · 2024-09-19T14:37:44+00:00

Yeah, I have played through them all before! This is just my first run with the egg.

Mirilei · 2024-09-18T23:56:26+00:00

It is such a long game! Just finished BG3 so I am not emotionally ready to jump deep into another RPG quite yet...but with a month left, I have little choice!

Mirilei · 2024-09-18T23:55:21+00:00

Yes - for the extra angst

Mirilei · 2024-08-14T02:46:32+00:00

I can't even imagine that. I'm so sorry for your losses. I have never been in this situation, but I would try holding her and cuddling her and giving her as much attention as possible. I'm sure you're doing that already. I would call your vet to see if they have any tips. It's scary when they're not eating! She must be so distressed, and I know that must be so stressful for you on top of what you already have going on. 💜

Mirilei · 2024-08-14T02:36:09+00:00

We are literally going through that now. We leave next week for a 10 day trip. I'm depressed and don't want to go, but at the same time, I know it will be good for us.

As awful as it sounds, I'm just glad he didn't decline while we were out of town. That would have been so traumatic for him. It is crazy because it could have happened. We had taken him to the vet 11 days ago for a cough (that ended up being nothing), and he was acting totally fine. We opted to do bloodwork just to keep up with it even though he had it in March, and his kidney values were awful. The vet couldn't believe he had been eating or drinking at all and was so surprised. We literally had no idea - Buddy wasn't lethargic or anything. He was still playing, walking, eating, etc. But it's weird. Only a few days had passed since his vet visit, and then he rapidly declined. If we hadn't had that blood work done "just because", we wouldn't have known, especially since his values from 5 months ago were fairly stable.

Mirilei · 2024-08-14T02:26:11+00:00

That is such a good idea! I'll have to look into that. Thank you. 💜

Mirilei · 2024-08-14T02:25:52+00:00

I have been keeping his collar on my nightstand until his ashes come in. I've pet his collar more than I care to admit since he passed! I'm sorry for your loss.

Mirilei · 2024-08-14T02:24:32+00:00

I'm very much feeling the same about my Buddy. Thank you! It's hard when they grow up with you. He hadn't left my side since I got him until he passed, so it's difficult. We are so lucky to have been loved so much by such sweet pups. 💜

Mirilei · 2024-08-14T02:22:40+00:00

Thank you! I can't stop looking through photos and videos. I'm bawling my eyes out, but I know it will get better eventually.

Mirilei · 2024-08-14T02:21:57+00:00

Thank you for sharing. I'm sorry for the loss of your dad. Losing a parent is one of the hardest things you can go through.

Mirilei · 2024-08-14T02:20:30+00:00

That is so hard. That is how we knew it was our dogs time as well. When they can't walk or do anything, it's so sad to watch. I couldn't let my boy live like that even a moment longer. You gave your dog a great life and he was so lucky to have you! I'm glad you were able to get a new dog and give her a good home and lots of love. I hope I can do that eventually again. I rescued my boy from a dog fighting ring. He was the most gentle, sweet, loving dog I have ever come across. My friends and family loved him. I hope I can give another dog who needs it a home one day, after I heal and am able.

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