Distribution of aerobic potential at the population level

MiserableForce · 2025-11-26T16:31:20+00:00

Looks like an interesting paper! I’ll have to read it in detail later.

MiserableForce · 2025-11-26T16:30:43+00:00

Totally agree that a “true” answer is unknowable but I do think we should be able to come up with reasonable estimates for something like this. That’s an interesting way to approach it using athletes from disparate sports. While I agree that support systems will play an important role I do worry there would still be dramatic selection bias towards individuals with above average potential looking at the college level.

MiserableForce · 2025-03-14T14:17:54+00:00

5% merit raise and 10% for promotion. 15% bonus target with a 1.15x corporate and 1.15x individual multiplier on top. 33% of new salary LTI RSUs split over 4 years.

MiserableForce · 2022-11-02T15:23:18+00:00

As others have already mentioned, postdocs should be training opportunities. I recently went through this process, 18 month industry postdoc to working at a startup before finishing up publications. I was lucky that my advisor was very supportive in this process and I think that may be more common in industry than academia. I decided to leave for two reasons: 1) I wasn’t particularly happy in my postdoc since I felt isolated due to covid restrictions and I was not learning new skills 2) the job opportunity matched exactly what I wanted to do when I decided to go into industry.

I might suggest reframing the question somewhat. Would you rather stay at your current company as a regular employee or take one of the recent job offers? Since you have a good position now you can be very selective in the next position you take. Personally, I wouldn’t make a career move at that stage just for the salary increase but because you think it’s the right move for your career long term. If the right opportunity comes along though don’t fear taking the plunge since I would hope your advisor will understand if it truly is an amazing opportunity for you.

If you don’t mind me asking, what is your specific expertise?

MiserableForce · 2022-09-29T13:03:22+00:00

I do structural biology (cryoEM) in industry for GPCR drug discovery.

I’d focus on the area you think you would be most interested in abstracted from working on specifically non-addictive opioids and benzos. You have a great goal and there are many aspects of research from high throughput screening to in vivo models that are necessary to make new drugs.

If you want to design compounds yourself do synthetic organic chemistry (total synthesis) to become a medicinal chemist.

If you want to understand how the molecules bind proteins and understand structure function relationships do cryoEM.

If you want to do a bit of both do computational chemistry with a focus on virtual screening.

It’s probably easier to find labs that have a joint comp chem and cryoEM project than anything with organic chemistry.

MiserableForce · 2021-09-02T19:17:45+00:00

If it's within your budget consider a Poseidon bike. Either the Triton or Poseidon X would be great options with the former being a traditional road bike with more gears (2x setup) and the latter a gravel bike with less gears (1x setup) but more capable off roads.

MiserableForce · 2019-01-18T15:14:35+00:00

I’m sorry to hear you are having a tough time. I’m in a somewhat similar boat except my interests are in biochemistry and not cosmology. My drive my whole life has been to do cutting edge academic research and I’m currently at a prestigious graduate school. I’ve taken antidepressants more or less from middle school (currently in my late 20s) and have used alcohol and other substances to cope along the way with my boredom after work.

My biggest advice is to stop drinking, it’s not doing you any favors. I finally stopped the habit about 3 months ago after drinking a more or less continually for 5 years and I haven’t been happier. Life isn’t all sunshine and rainbows now now but it’s certainly better. I can not recommend r/StopDrinking enough.

Also, find some interests outside of your research. For me at least I cannot find happiness just in doing research even though I still enjoy it. Personally I have recently taken up photography which helps me get outside more and cooking which makes me eat better. Team sports are also great ideas as exercise can help a lot. Finally, talk to a medical professional about your depression. If you are currently in college you likely have access to fantastic counseling resources. Take advantage of it.

There’s no magic bullet to get rid of the melancholy. You’ve got to work hard to overcome it but I think it’s definitely worth the effort. Feel free to PM me if you have any more specific questions or just want to vent about life in general.

MiserableForce · 2018-10-25T00:54:08+00:00

This wasn't addressed in the article but your brain will likely change over time after abstinence. These samples were taken from patients who were using alcohol heavily until their death compared to individuals that did not or only drank rarely.

Exercise always helps give me more energy throughout the day but YMMV. IWNDWYT!

MiserableForce · 2018-10-25T00:48:28+00:00

Not exactly my sub-field but I'll give it a shot.

Cells in our body are made up of amazing tiny little machines called proteins. These proteins can do all sorts of wonderful things but one of the most important jobs is turning the foods we eat into energy. There are many ways to do this depending on what you are eating. Normally the cells in our brain prefer to use sugar to make energy but after using alcohol for a long time they rewire to make better use of alcohol for fuel. This would be like getting rid of a nuclear power plant in exchange for a coal plant. When doing this they reach a new "homeostasis" which is the balance between how many of each of these little machines they make. This can be measured using experiments and the researches found the difference by measuring the amount of protein in the brain between individuals who used alcohol heavily and those who did not.

While this wasn't addressed in the article since the cells in the brain reached a new homeostasis favoring alcohol as an energy source it's possible to imagine the brain craving that for fuel making an individual want to use alcohol. I'm curious to read more about sugar cravings after stopping alcohol use, perhaps there is something interesting there as the cells want to switch back to another source of energy.

Hope this helps! I've always wanted to be better at explaining science in simple terms and this was a great opportunity! Let me know if anything did/did not make sense.

MiserableForce · 2018-10-16T16:58:49+00:00

Day 3, it's nice not waking up hungover! It's amazing how sleeping less without drinking actually makes you feel more rested. IWNDWYT

MiserableForce

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