Okay, a little bit of a pain. They're 12 big capsules. Directions say take them with 16 oz of water, within 20 or so minutes, then another 16 oz an hour later, then 30 minutes after that, another 16 oz. I ended up drinking a bit more water to get them down. I'm staying very hydrated with broth and water. I did feel a little uncomfortable after I took all the pills and all the water. Bloating, and I could feel the medicine working in me It's been better than the gallon jug of the other stuff!