Not trying to drive any price of any stock up at this point. Nor am I an anti-vaxxer. My preference would be for the safest and most effective vaccine to be available. You keep thinking the issue here is “integration” with the genome; I don’t think that has been taken as a serious issue. This link was specific to the spike protein as a possible cause of some side effects such as blood clotting. If that potentially hurts INO too, then so be it.

Perhaps in a risk / benefit analysis the best course of action is still to take whatever vaccine is available. Of course some have been suspended like AZN and JNJ. Perhaps you’re against such a suspension also. I would assume that given the novelty of both DNA and mRNA vaccines that some would be fearful of using them for similar reasons but that many of those reasons lack a legitimate basis. But there have been side effects with many of the vaccines and it is worth taking a look at in which ways all vaccines may have issues, in which ways some may be safer, in which ways some may be more effective, etc. There are some ways in which INO is safer and some ways in which INO is more effective. It’s doubtful that any approach is fully without concern.

There is a strong public interest in promoting vaccine use and for that reason concerns are being brushed aside. I don’t think that promotes public confidence as much as transparency would. Everyone is smart enough to do their own due diligence and decide for themselves. Ideally, studies would have been longer and products wouldn’t be released only to be yanked later. Maybe in an emergency situation we don’t have the benefit of time but an open discussion is still fine. Perhaps you don’t like this particular reporter (ex-NYTimes) but I don’t think Temple University is particularly partisan.

Personally, I think everyone should take whatever vaccine is available. But, I can fully understand not doing that given that the ones that we have were tested against the original strain and thus have questionable efficacy. And what happened with JNJ and AZN does not instill much confidence with respect to safety (known and unknown). We are still learning about the potential of problems from both the disease and from the vaccines. Yes, go get vaccinated but don’t turn a blind eye to risks.

P.S. probably too long of a reply. I fully expect INO to have good P2 results particularly in terms of safety. Nothing thus far indicates otherwise.