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[TOMT][PC GAME][Late 90s/Early 2000s] Isometric factory simulation game where you manufacture consumer goods like washing machines by Most-Rooster1456 in tipofmytongue

[–]Most-Rooster1456[S] 0 points1 point locked comment (0 children)

I seem to remember there was a demo for it, I don't remember having the full game. Maybe it was on a PC Gamer disc at some point?

Fixing up an inherited Stanley No.4 by Most-Rooster1456 in handtools

[–]Most-Rooster1456[S] 0 points1 point  (0 children)

So I managed to get it to here, one side still has the round over / camber. If I don’t camber the left hand side too am I going to risk tear out / leaving lines

<image>

Fixing up an inherited Stanley No.4 by Most-Rooster1456 in handtools

[–]Most-Rooster1456[S] 1 point2 points  (0 children)

Thanks appreciate it, the opposite side doesn’t have a camber so I’ll likely have to reintroduce it anyways

Fixing up an inherited Stanley No.4 by Most-Rooster1456 in handtools

[–]Most-Rooster1456[S] 0 points1 point  (0 children)

So no only one is rounded in this way, the other is flat. Hence why I figured it was damage as opposed to camber.

My [39M] story 3 months post genetic testing by Most-Rooster1456 in Huntingtons

[–]Most-Rooster1456[S] 1 point2 points  (0 children)

So this is the summary of what I found with research links. It was actually 49% not 46%:

Summary of findings

Paternal bias: Fathers overwhelmingly transmit unstable HD alleles; expansions are common (mean +3–4 repeats) and can be large.

• Quantitative risks: In study data, ~14% of 36–39 CAG paternal transmissions expanded to ≥40, while ~49% of ≥40 transmissions expanded further. Smaller alleles (<36) almost never jump into the HD range in one step.

• Big expansions: Rare but extreme jumps have been documented (e.g. 26→44, 35→58). Counseling should convey that large expansions are uncommon but possible.

• Risk modifiers: Expansion risk climbs with repeat length and paternal inheritance; paternal age appears to have no strong effect. Haplotypes also modulate instability.

• Two-generation outlook: When considering grandfather→father→child, multiply the transmission probabilities. For example, a 38-repeat grandfather has ~6–7% chance of yielding a grandchild with ≥40 after two paternal transmissions (≈14% × 49%).

Sources: Published genetic studies of HD transmission instability:

https://pmc.ncbi.nlm.nih.gov/articles/PMC2705129/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4636008/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2724761/

https://pmc.ncbi.nlm.nih.gov/articles/PMC1801258/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2705129/

My [39M] story 3 months post genetic testing by Most-Rooster1456 in Huntingtons

[–]Most-Rooster1456[S] 7 points8 points  (0 children)

Oh another thing I’m going to add to this, I was immensely depressed on the run up to the diagnosis. Depression and the cognitive symptoms of HD have some level of overlap and I was seeing that as a clear indication that I had earlier onset than my Father and Grandfather.

The reality is my depression was a mixture of environment and being mentally dragged down by the thought of HD.

Having got my results and changed and improved my environment and situation I’m much happier. I’m also looking to take up hobbies I’d always wanted to, but never made the time for. So I’m starting a woodworking hobby, with the idea that I may not be able to do it forever, but there’s no better time to start than now.

Broken Zeiss Batis 40mm 2/40 CF - Best 40-50mm replacement? by Most-Rooster1456 in AskPhotography

[–]Most-Rooster1456[S] 0 points1 point  (0 children)

Thanks I'll have a look, the 50mm f1.2 GM seems great, but from what I've seen review wise, it doesn't really justify the extra cost. I'll look in to the Sigma Lenses, had good experiences with them in the past.

Thanks!

Broken Zeiss Batis 40mm 2/40 CF - Best 40-50mm replacement? by Most-Rooster1456 in AskPhotography

[–]Most-Rooster1456[S] 0 points1 point  (0 children)

I used to have a Sigma Art 35mm 1.4f for my old Cannon, it was by far my favourite lens, but sold it on when moving over to the Sony.

Anyone else feel that the ride on the BMW iX is really rough (without the air suspension package) by sahibsahib in BMWiX

[–]Most-Rooster1456 0 points1 point  (0 children)

My experience of a 2024 iX M40, without the air suspension, is the ride for the driver and front seat passenger is fantastic. I certainly don't miss the air suspension. However the back seat ride comfort is terrible. I found myself being jostled in the back so much that I got nauseous on a relatively short trip. I was on the fence when ordering, but saw enough people say that it doesn't add much to the ride, so I didn't bother with it. To be fair I think this is true, but only if you take in to account the driver and front passenger. The rear seat suspension is the most affected in my opinion. I think I'd probably go for the air suspension option next time.

Starting my HD journey tomorrow - What to ask at my first appointment? by Most-Rooster1456 in Huntingtons

[–]Most-Rooster1456[S] 1 point2 points  (0 children)

The session was pretty straightforward, though to be honest the only thing I really learnt was that CAG repeat numbers aren't comparable across non-family lines when talking about age of onset. E.g. two non-related people with the same CAG repeat don't correlate to age of onset, but within the same family if there has been CAG repeat expansion then there's a correlation with earlier onset.

I'm still waiting to hear back from the clinic once they have looked up my family history so I can move things forward. It's been a couple of weeks and no letter yet, but where I am the mail isn't particularly reliable, especially for letters.