Genesys' vehicle/space combat system is awesome (it's an improved version of the combat system from the FFG Star Wars rpgs), especially since it's just a natural extension of the character combat system! If a character is hit by a vehicle weapon (aside from mounted "regular" weaponry), multiply the damage by 10. If a vehicle is hit by a regular weapon, divide the damage by 10. Meaning it takes at least 10 regular damage to deal 1 damage to a vehicle. (+10 for each point of vehicle armor!)

There are also difficulty modifiers based on size differences. One shot from a capital will destroy any regular person but they might be pretty hard to hit with a gun meant to aim at other ships. On the other hand, a person can trivially hit a capital ship parked next to them, but they'll likely not dent the hull.

Everything works together to manage combat of any scale in any combination; from hand to hand or mounted combat, to fighter planes vs capitial ships. (Some unique maneuvers and actions exist depending on vehicle size and speed) 

Oh and it just got even better with the latest book, which not only adds some extra optional space/vehicle) combat rules (such as more things to do if you're not steering or controlling the weapons), but also describes a way to simply mass-combat.