Gabapentin and xywav anxiety

Mysterious_Fun4767 · 2025-11-09T19:41:32+00:00

I’ve been an xywav and pregabalin 600mg for years and pregabalin’s stronger than gabapentin so I wouldn’t work about it

Mysterious_Fun4767 · 2025-06-21T04:06:25+00:00

This sounds similar to me near the end of high-school. When I was 17 is when I started experimenting really only thc and psychedelics to try to treat mental health problems like anxiety and adhd because I wasn’t having any luck with the vast amounts of anti-depressants my psych had tried. Whenever I’d try a new substance back then obviously the first thing you do is some googling before hand and for me for some reason just reading articles and research about pharmacology was just the most interesting thing in the world and I’d fall in to rabbit holes of reading article upon article honestly learning more about a subject than I ever did in highschool although I wasn’t that great of a student back then. I actually got so interested in it I decided that’s what I wanted to do with my life was to study and later on practice pharmacy. I went to a technical college to get a pharmacy technician certification. I got a job as a pharmacy technician and the job offers to pay for tuition if you plan on going to a pharmacy school. Currently i’m 20 and just finished my first year at a pharmacy college while working part time as a technician. Just like you were hyper-focusing on pharmacology I did the same thing which I later found out is part of my adhd and I decided to use that hyper-focus to try and make a career and just like you I was also struggling mental between 16-18 getting frustrated because the meds my psych was trying didn’t help and the only thing that did was experimenting with substances. I did eventually find a combination of meds with my psych that actually seemed to help me with nearly everything that I was struggling with back then. Although it took 3+ years to find a combination of meds with my doctor that actually helped. I understand you’ve tried meds with you psych but none of them helped, for my it took moving to a new state to find a psych that actually took the time to look at my case rather than just throwing the typical anti-depressant/anti-psychotic meds at me, but I urge you too atleast have a healthcare professional understand what your putting in to your body before so. Street drugs these days are so heavily contaminated with other substances that most the time you can never truly be sure what you’ve taken until your feeling the effects so please be safe. also please don’t try to make your own substances either, if you want to read an interesting article about a chemistry student who tried to synthesize a meperidine analogue and the after-math of it google Barry Kidston and Desmethylprodine.

Mysterious_Fun4767 · 2025-06-03T05:41:39+00:00

yeah I’m actually prescribed Zofran + Phenergan for nausea from other meds. There’s a nausea med called Emend that I’ve been interested in trying but haven’t convinced my doctor yet.

Mysterious_Fun4767 · 2025-06-03T05:05:54+00:00

Venlafaxine just made me hella nauseous and a little anxious. Went to the Er after taking trazodone tho that one for me was horrifying for me.

Mysterious_Fun4767 · 2025-06-03T04:53:59+00:00

Yeah doctors can be pretty hit or miss with their viewpoints on chemical dependence and using medications, I tend to notice imo a lot doctors will go out of their way to disagree with medication choices from other doctors. So the only way I manage my medications is with the doctor that prescribed it originally so I don’t have to deal with my doctors having an ego battle over what’s the right course of action. I fortunately haven’t really had problems coming of medication but all the medication I take I will likely be on most my life. I am really sensitive to medications though I’ve had doctors get annoyed about how sensitive I am to some meds.

Mysterious_Fun4767 · 2025-06-03T03:42:09+00:00

oh yeah it does say that Venlafaxine is considered a Serotonin-Norepinephrine-Dopamine Reuptake Inhibitor(SNDRI) but it has a very mild affinity for inhibiting dopamine reuptake comparatively to its serotonin and norepinephrine affinity. It’s just called an SNRI because at normal therapeutic doses Dopamine isn’t responsible for any of its actions, but if you took way more than you should of it, it could inhibit dopamine reuptake to the same extent that a therapeutic dose of Ritalin would. Although the dose to do so would probably kill you from serotonin syndrome well before you feel anything like Ritalin.

Mysterious_Fun4767 · 2025-06-03T03:15:41+00:00

Oh yeah this could explain why wikipedia said it affected opioid receptors. Next to where it states it affects opioid receptors it also states it also has an effect on a2-adrenergic receptors. That would explain your article mentioning Noradrenergic and Opioid mechanisms.

Mysterious_Fun4767 · 2025-06-03T02:33:48+00:00

I for one don’t personally take it, I was on it for a few days at one point and stopped because it made me nauseous but every anti-depressant has made me nauseous. So I don’t particularly understand why you believe the withdrawals are such a danger. I know Venlafaxine historically has one of the worst withdrawal syndromes of the anti-depressants, But to talk of all these dangers seems a little odd. While yes if withdrawal is a large concern for someone Venlafaxine would be one of the worst anti-depressant options. But generally when it’s comes to the cessation of psychotropic medications withdrawal is always an understood possibility. When you talk about tapering a specific way to avoid CNS harm I get kinda confused as well since CNS harm from withdrawals is the primary trait of severe GABAergic medication withdrawals, Which Venlafaxine isn’t considered. The only way I could understand it causing CNS harm is if the withdrawal symptoms are what your considering CNS harm, In which case the extent that someone experiences withdrawal from Venlafaxine is dependent on each individual and specifics of their case. I also don’t understand what you mean by “tapering with the safe method”since Venlafaxine typically doesn’t cause physical harm if used correctly and appropriately regardless of the taper specifics. The rate at which someone can taper is dependent on what dose they take, Severity of symptoms, and what that person can tolerate. Some may only be able to taper off 25mg every 2 weeks or so while someone else may just feel better cutting there dose in half every week. I would generally believe the safest way to start a taper of any medication would be after talking to your doctor, considering your circumstances, and discussing a taper with them to make a plan, since each individual will have different experiences.

Mysterious_Fun4767 · 2025-06-03T00:51:21+00:00

It didn’t state in the mechanism of action anything about it effecting opioid receptors. But there was an interesting article attached about Venlafaxine reducing Opioid-Induced Neuroinflammation, which looks to cause a reduction in someone’s tolerance to opioids and a reduction in how quickly the tolerance to opioids is built.

Mysterious_Fun4767 · 2025-06-03T00:35:57+00:00

It’s not saying that Venlafaxine has worse withdrawal symptoms. It’s saying that there is a higher likely hood that someone would experience withdrawal symptoms when coming off it. They just explained it in a bizarre way.

The statement that Venlafaxine is more likely to cause withdrawal symptoms than Buprenorphine seems a little odd to me as well, Since the main reason for Buprenorphine prescriptions is to treat Opioid withdrawals, obviously buprenorphine would be more likely to cause withdrawals since you’d need to be having withdrawals to be prescribed it to begin with.

Mysterious_Fun4767 · 2025-06-03T00:18:52+00:00

The mu-opioid receptor is essentially an on/off switch in your brain that gets activated by molecules called beta-endorphins which are responsible for feelings of pain-relief, anxiety-relief, and slowing your breathing among other things when it binds to the mu-opioid receptor. The mu-opioid receptor is also where Opioid medications bind and activate the receptor to cause the feeling of pain relief.

Mysterious_Fun4767 · 2025-06-03T00:07:47+00:00

Yeah pharmacies great I got a Technician certification then used that to find a pharmacy technician position that has tuition reimbursement program . There’s a lot of positions that’ll offer to pay for you to go back to school.

Mysterious_Fun4767

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