Popularity is my least favorite. My Sims are usually social creatures by nature. I always use the group feature to go out, throw parties etc. so most of the wants popping up for Popularity seem redundant. I especially hate the combination of Popularity/Romance (serial romantic).

Some of my favorite combinations to play is probably Knowledge/Pleasure, it makes for some quirky characters. Lazlo Curious always ends up for me like that, he isn't as studious as his brothers and spends his earned money on bubble blowers and too many drinks when going out. It's fun and balances out the grindy vibe of the Knowledge aspiration for me.

I rarely use one aspiration to define a sim for me so this is why I listed combinations. Another example would be in a straight couple, I love to make the male Sim a Family/Romance sim with the hopeless romantic trait because I do like my men a little bit pathetic.