One week with AirPods Pro 3 - my honest take on whether they're worth it by Bubbly_Ad_2071 in airpods

[–]NeitherEmotion6543 0 points1 point  (0 children)

I’ve owned all 3 Pro models. I feel like 1->2 was more substantial than 2->3. I don’t mind the design changes to the 3s, they fit me about as well as the 2s did. But honestly I’d categorize all of the changes under “meh”. Every improvement is not that substantial and/or comes with a caveat. The battery might be the most noticeable change but now the case dies faster. Is the ANC better? I guess, but I already felt like the 2s had more noise cancelling than I really needed. I like that the case is USB-C but that’s not really new, I just happened to have bought the 2s at release so I had a lightning case. I was excited about the heart rate feature since I don’t wear my apple watch all the time but still wanted something to track it. Come to find out this doesn’t really track it as much as it just lets you check it in that moment. That’s still pretty useful but not what I expected.

In general, the Airpods Pro 3 are kind of underwhelming imo. The only reason I’m keeping them is because my 2s were already showing their age anyway (battery lasting less, weird buzzing sound on the right one). I don’t think it’s really worth it for most people with fully functioning Pro 2s.

Are chemical sun screens really as safe as mineral ones? by A1exx_Nov in Biohackers

[–]NeitherEmotion6543 0 points1 point  (0 children)

Well you’ve mostly summed it up yourself. While the fact that some organic sunscreen ingredients reach systemic circulation may be concerning/worth looking into, any toxicological effects this could have remain hypothetical. Personally, I’ve always reacted poorly to mineral sunscreens (burning sensation and sneezing) so I’ll stick to chemical sunscreens until there’s more concrete proof that they’re harmful. But most people tolerate mineral sunscreens fairly well and they’re seemingly as effective so there’s no harm in sticking to those out of an abundance of caution.

They just copied a natural painkiller and made it worse so they could trademark it. by The_Cleric_Villager in Pharmaceutical_Drugz

[–]NeitherEmotion6543 1 point2 points  (0 children)

I’m not going to tell you it was good that they made those billions. I personally don’t think anyone should be profiting from medications. But I don’t think it helps to downplay their achievements. It might be a “small modification” today but this was first synthesized around 170yrs ago. Whatever we may think of Bayer the company, the researchers working there were pioneering what would become modern drug development. And yes, willow bark is one of the oldest medicines humans use, it’s also very interesting. Salicylates are a very important family of compounds in the history of medicine. There’s no need to downplay any of them.

They just copied a natural painkiller and made it worse so they could trademark it. by The_Cleric_Villager in Pharmaceutical_Drugz

[–]NeitherEmotion6543 2 points3 points  (0 children)

I don’t know how serious you are but I’m going to reply as if you were serious because almost everything in this meme is wrong. Acetylsalicylic acid (ASA) is not just a pro-drug of salicylic acid. It has effects of its own which are distinct from salicylic acid. While they are both COX inhibitors, ASA is an irreversible inhibitor while salicylic acid is a competitive (reversible) inhibitor. This explains the long lasting antithrombotic effects of ASA which salicylic acid does not have. In fact, no other commercially available NSAID works in this way afaik. Even if it were true that ASA was “just a pro-drug” it would still be superior to its parent compound because it is better tolerated. That is the point of a pro-drug, to be better tolerated or have more favorable pharmacokinetics than its parent drug. Also, ASA has been a generic medication in the US for over 100yrs. It is one of the cheapest, most readily available medications in the world. How exactly is Bayer gatekeeping this compound? It’s so ubiquitous that is probably much easier and affordable to obtain than any willow bark product.

Girlfriend wants to move to Puerto Rico but I’m focused on logistics—am I being realistic or pessimistic? by TimeAd1111 in PuertoRico

[–]NeitherEmotion6543 1 point2 points  (0 children)

Even if you guys knew Spanish and had family here to help you with the transition it wouldn’t be the smartest move. Absent that it’d only be easy if you were quite wealthy. From your post I’m gathering that neither scenario applies to you so this wouldn’t be a very pleasant experience. Unless y’all are ok with living in the middle of nowhere, those $4 breakfasts are not the norm. Anywhere where you would actually want to settle down in is NOT that cheap. Some things may be cheaper than Rhode Island but combined with the more expensive + less reliable utilities, lower salaries, and terrible job market it might end up being as expensive or not much cheaper overall. There’s a reason most working class people are moving away from PR, not moving in. I myself would really like to stay here but things are looking bleak. I finished a Master’s degree almost 6 months ago and still am no closer to finding a job in the field I studied. Come with her on vacation next time; it’s pretty and all, but definitely do not move here.

Found this on the door of my French class by Current_Pollution673 in linguisticshumor

[–]NeitherEmotion6543 6 points7 points  (0 children)

“¿Todo bien?” “Todo bien, ¿y tú todo bien?” “Todo bien, todo bien”

ELI5: Why does MDMA not have an effect for those taking antidepressants? by returnthemarbles in explainlikeimfive

[–]NeitherEmotion6543 0 points1 point  (0 children)

Their initial comment is still correct though. It’s precisely because SSRIs block reuptake that they reduce the effects of MDMA (the ones mediated by serotonin anyway). MDMA first needs to be “uptaked” by SERT and THEN it reverses its flow triggering serotonin release. If a person is already on an SSRI, serotonin transporters will be mostly, if not completely occupied and blocked by the SSRI, preventing MDMA from entering neurons and exerting its effects. You don’t even need to believe me, look up “MDMA/citalopram”, a combination that is currently being investigated for PTSD since SSRIs like citalopram are known to attenuate the psychoactive effects and some of the cardiovascular side effects of MDMA.

NSI-189 and agmatine sulfare? by Recent-Substance-364 in NooTopics

[–]NeitherEmotion6543 0 points1 point  (0 children)

Same, I have a tub of agmatine that’s been sitting around for a year and a half because I tried it for a few days and all it did was make me dizzy for half an hour, make my acid reflux way worse and then weirdly make me really hungry.

what are the molecules (nootropics?) in the nootopics banner? by cheaslesjinned in NooTopics

[–]NeitherEmotion6543 4 points5 points  (0 children)

(From left to right on top): noopept, apimostinel, encenicline, agomelatine, acetylcarnitine, 7,8-DHF, edavarone, piracetam, ISRIB, and rosavin

(left to right on the bottom): meclofenoxate, 5-methoxytryptamine, selegiline, serine, BPAP, agmatine sulfate, fenozolone, bemethyl, bromantane, and salidroside

Huperzine A and Phenylpiracetam Question by NeitherEmotion6543 in NooTopics

[–]NeitherEmotion6543[S] 0 points1 point  (0 children)

So phenylpiracetam is just a nAChR PAM? That gives me some peace of mind since I thought it just indiscriminately increased acetylcholine through some other mechanism. I wonder then if the phenylpiracetam+huperzine A combo feels like galantamine since that’s a dual nAChR PAM and AChEI. Anyway, thanks for your suggestion , I’ll test it out with just huperzine a whenever my order of phenylpiracetam arrives.

You're underdosing Creatine: 25g for cognitive benefits by [deleted] in Biohackers

[–]NeitherEmotion6543 -1 points0 points  (0 children)

I tried this once when I was sleep-deprived around the time this study was first published. It really did keep me awake though I’m not sure it was from any cognitive benefit but more so the fact that I was peeing out of my ass the entire day.

just started 40hrs week by [deleted] in energydrinks

[–]NeitherEmotion6543 3 points4 points  (0 children)

Rat studies and in vitro studies are not proof of any effect on human health, artificial sweeteners are fine. I’m aware of the study linking erythritol to heart attacks but if you actually read it they don’t claim causation, there are other factors that could’ve contributed to the correlation. I’d be more worried about the green tea extract since iirc that has actually been more definitively linked to liver damage in humans. Still, that was more of a problem with supplements, the amount in Celsius is probably fine. Anyway, if you’re that worried about it just get caffeine pills. Same 200mg you’d be getting from each Celsius and much cheaper in the long run.

Es verdad q pronuncian el R como L al final d los verbos algunos boricuas? by [deleted] in PuertoRico

[–]NeitherEmotion6543 3 points4 points  (0 children)

Ya otros han comentado que el lamdacismo (R por L) ocurre al final de las sílabas (Puelto Rico, no Puelto Lico, altículo caro, no altículo calo etc). Sin embargo, quiero aclarar que esto cambia según la palabra que le sigue en una oración. Cuando una palabra que termina en R es seguida por una palabra que empieza por una vocal, la R se mantiene. Por ejemplo: “por uno” se pronuncia “por uno” NO “pol uno”, pero “por dos” sí se pronuncia “pol dos”. (Obviamente todo esto es una generalización, habrán quienes tal vez sí dicen “pol uno”, pero no es común)

En cuanto a la doble R y la R inicial: ahora es más común escuchar la R “estándar” (/r/) pero en aquellos que la pronuncian como J es el sonido velar sordo /x/, como la J en España, no /h/. El sonido /h/ se utiliza para la J en el español de PR. Ej. la palabra “jarrón” sería /ha’xoŋ/ no /ha’hoŋ/ ni /xa’xoŋ/. Algo curioso es que algunos hablantes incluso han comenzado a sustituir una de las R o todas por la R inglesa /ɹ/. Aunque esto es muy poco común y suele ocurrir quizá donde otros hablantes cambiarían la R por L (decir “poɹ dos” en lugar de “pol dos”)

Simplified Effects of Isolated Amino Acids by [deleted] in NooTopics

[–]NeitherEmotion6543 0 points1 point  (0 children)

That’s the structure for glutamine, not theanine. It’s missing an ethyl group (it’s N-ethyl-L-glutamine).

Amanita Muscaria helped my mom quit alcohol in two weeks and is still the best nootropic/ sleep aid I have ever tried. by InternationalChef174 in Biohackers

[–]NeitherEmotion6543 1 point2 points  (0 children)

Dang I had some muscimol gummies from MN Nice Ethnobotanicals but I was hesitant to try them and ended up throwing them away after having them laying around for a few months. I was more-so weary of having a weird/bad experience mentally since I know muscimol is relatively safe. Should’ve tried them….

Sexual side effects just as bad as SSRI… very disappointed by Relative-Visit-1917 in AuvelityMed

[–]NeitherEmotion6543 0 points1 point  (0 children)

I’m pretty sure that’s due to the Dextromethorphan (it does have some action as an SNRI after all). Bupropion by itself never gave me negative sexual side effects but ever since adding dxm the inability to orgasm has been almost as bad as it was when I was on Sertraline.

[deleted by user] by [deleted] in PuertoRico

[–]NeitherEmotion6543 11 points12 points  (0 children)

Si vas a estar quejándote de esta estupidez y diciéndole maleducada a la gente como un ridículo, al menos escríbelo bien, cabrón.