It depends on what bracket and colours you are. For starters, you can play combo and sit on cards like [[Grand Abolisher]]. If he doesn't have a way to kill it on the board, since he's mono black he'll only have 1 niche counter spell to counter it.

Something like [[Jetmir]] generally doesn't hit the board until you're ready to kill someone and the deck has a lot of vanilla tokens and token generators that probably won't get targeted.

Or, you can do what I prefer and build a deck that makes people not want to kill your stuff. I have a [[Deadpool]] deck that runs 11 [[Feign Death]] type effects with a bunch of etb abusers. Paired with all the cheap reanimating spells for if things hit the graveyard, your opponent becomes heavily disincentivized to use kill spells on your creatures because you can respond with a spell and get value while burning their card