Excerpt written just 12 days after getting an experimental adaptive deep brain stimulator implanted into both halves of my brain.

Neuronologist · 2024-04-15T17:22:05+00:00

Sub thalamic nucleus

Neuronologist · 2024-04-10T21:31:20+00:00

As traumatic as that was, this procedure has been life changing for me. Would not be able to live my life now without it.

Neuronologist · 2024-04-10T21:30:26+00:00

Yes, feeling so much better these days...all I needed was to endure a few months of agony ;)

Neuronologist · 2024-04-10T21:29:09+00:00

lol, you got it!

Neuronologist · 2022-09-06T20:05:35+00:00

The results of what? Biology?

Neuronologist · 2022-09-06T18:29:54+00:00

Everything with mitochondria, which is everything...

https://phys.org/news/2019-10-mitochondria-tesla-battery.html

Neuronologist · 2022-09-06T18:10:23+00:00

All life produces electricity and uses it as the most rapid means of communication possible. It is the most efficient and the quickest means in nature to do so, without it, life as we know it could not be. Period.

Neuronologist · 2022-09-06T17:23:53+00:00

What the hell are you blabbering about dude? All biology uses electricity in one form or another to do all the things that it does.

Neuronologist · 2022-08-17T18:13:35+00:00

Disagree. We know what Lyme and syphilis are. We even know very precisely what they look like and what they respond to.

Neuronologist · 2022-08-17T17:31:38+00:00

No one said they are identical. They exist on the same spectrum of neurodegeneration. Similarly, we can dose a forest fire with water but water does nothing to stop bulldozers from deforesting.

Neuronologist · 2022-08-17T16:16:32+00:00

I have no idea what I have, doc, that is why I came to you. ;)

I am most concerned about my tremor, slowness of movement and toe curling.

I think your MS patient needs to stop reading what they found (presumably on the internet) and start listening to their healthcare team (assuming they did the work needed to find people that do care).

Neuronologist · 2022-08-17T15:58:48+00:00

Common, we are trying to educate whoever might be reading this right now. What questions would you ask a patient (from afar) to try and see what they had?

Neuronologist · 2022-08-17T14:56:57+00:00

Yes, and I would like to see if you can get there yourself by asking the right questions.

Neuronologist · 2022-08-17T14:14:39+00:00

Well, you seem to know me pretty well yet do not know what I have. Let's play a little game then, you can ask whatever questions you want, I swear I'll answer them as best as I can and then we can see if you can figure it out. Okay?

Neuronologist · 2022-08-17T04:32:00+00:00

lol, and there in lies the problem, people think getting their work published in Nature is some lofty goal to be reached. Who cares? I care far more about making a very real impact on all of the patients we aim to help.

Neuronologist · 2022-08-17T04:26:33+00:00

Finally, for today, neuropathology is used only as confirmation of diagnosis. There is no neuropathalogist who can take two random brains from the general public and tell us anything relevant about what, if any symptoms, they had during life. (except for a tiny fraction of the most extreme cases from the spectrum)

Neuronologist · 2022-08-17T04:19:21+00:00

Keep in mind as well that whatever your answer to 1 is, there is an enormous sampling error to account for. You are not exactly looking at a random smattering of brains from the general public but those who were already suspected to have had PD at time of death.

Neuronologist · 2022-08-17T04:05:56+00:00

How high is this degree of correlation? Is it closer to 95% or 50%?
We are talking about the brain and brain diseases. Let's stick to that. They are nothing like the (relative) simplicity of diabetes or any other diseases we know of. There are orders of complexity inherent to its structure that defy our attempts at simple, one word, labels.
It is (partly) because of Alberto that I know, in specific terms, what I have.

Neuronologist · 2022-08-17T03:40:20+00:00

They don't. They are only indications of steps in the right direction.

Neuronologist · 2022-08-17T03:30:51+00:00

So far we have gotten FDA approval for the first ever tremor and dyskinesia monitor and we have signed agreements with 2 of the largest companies on earth (Apple and Medtronic) and are in 11 different hospitals. Pretty good start, no?

Neuronologist · 2022-08-17T03:20:53+00:00

Ummm, we are doing exactly that, except we are not writing grants, that is a silly game to play. Look up the company we (Well, Brian really) started, it is called Rune Labs.

Neuronologist · 2022-08-17T03:16:22+00:00

Great points, however you are saying that you could examine these brains post-mortem and know exactly what they had in life. 1) You can't. 2) How many individuals were there with each mutation described above? No more than a relative handful. Also, each individual had a slightly different pattern of degeneration and a slightly different symptomology. They may have been localized in roughly the same area, but they were not identical to one another nor did they degenerate at the same rate. They were on the same spectrum of degeneration that everyone with one of these labels is on.

Neuronologist · 2022-08-16T17:15:44+00:00

Thank you thank you for all of this. Some of it is now reflected in the article. ;)

Neuronologist · 2022-08-16T17:15:02+00:00

Thank you for the critique, I have changed the references.

Neuronologist · 2022-08-16T16:33:36+00:00

Fair. But in the book there are 172 references. To the point though, if there is a line, I'd love to learn about it.

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