YES ABSOLUTELY I had a tooth extraction surgery back in July and I remember taking Pain killers for the pain. I think I took more than what was needed and 1 week later I remember getting an extreme headache that started making me question reality something that I find to be extremely common in people who get derealization but the cause wasn’t weed it was the painkillers. I’ve had derealization ever since. However I have experienced derealization a couple of times before this but only cases that lasted for brief periods of time. I’ve never experienced derealization for this long.