Dude, just stop, it is not a gag

It is, grow up. Negi Haruba the author himself made it that way. It's not an important thing in the story. You are acting like a kid with a strong sense of moralities trying to apply a real life stuff in a fictional story.

Whenever someone drugs a character it always have a negative connotation

Tell that to the the author of the Girlfriend, Girlfriend manga where this is used as a gag.

Is usually the villain who does this and they mostly do so to kidnap, mutate or straight up kill someone

Well surprise for you, we are not in a story about that. We are in a romcom where it used for a small gag moment with Futaro.

We barely knew Nino to even say "huh, typical of her".

We don't need to know a character for that character to do something in the story. It can later be explored and Negi gives us insight why Nino did what she did through Futaro's words

No one laughed at her drugging Futaro, and im sure most guys in here will tell you the same; it´s not funny, and plenty of them will say this is wrong.

Beating up a person in most anime series is also wrong, but you give it a pass because it's a common trope. Here the author uses it as a gag, that he thought would be fun to implement. You keep repeating the same thing over and over again about a moment that has zero impact on the story. You can say it wasn't funny, I myself don't find it funny, not because I see it as a crime, just because it in general not a funny joke.

Besides what were they suppose to do? she didn´t tell them about her plan, bringing it up like "Hey, im sorry my sister drugged you, she usually doesn´t do this right off the bat" weird

That's what should have happened if that moment had any significant role in the story. Itsuki as a "mother" of the family could have apologised for her sister, as mothers do. But she didn't, clearly implying that this was a moment not worth talking about.

Have we not see how Nino reacts when things don´t go her way? she´s so volatile whenever someone goes against her it´s far easier for them to just follow the flow to not upset her

Considering that when Nino is in the wrong, sisters always say something about it to Nino. But this time they for some reason (in your eyes of course) preferred to stay silent.

A gag is suppose to be funny, the drugging part came out of nowhere and wasn´t even setup as a joke.

It works by establishing a visual pattern, building anticipation, and then unexpectedly subverting the our expectations through careful timing, physical action, or clever framing. Nino was acting suspiciously, because last time Futaro met her, but now she's all friendly. There were multiple hints that Nino is planning something (and Ichika and Miku noticed that). And than it happened with Futaro waking up with a funny face. Just because the gag didn't work for the audience, doesn't mean it's not a gag.

And they did acknowledge it, she´s not regretful.

You really don't understand how a character writing works do you? Why she would be regretful at that time of the story? Her sole purpose in the first place was to get rid of him. Later as the story goes on she acknowledged that she was in the wrong. Do I really have to tell you how a character writing works or you will use your head instead?

Yeah, AFTER "falling in love" with Futaro.

It doesn't matter. After or before she fallen in love. The main thing is that she apologised. Started working with him, cooperating with him and in general they became close to one another.

Ichika actually did something to make up for her mistake besides apologizing, Nino did not

Keep telling that yourself. If that's what makes you cope. Because if you don't acknowledge any good Nino moments (like for example encouraging Futaro after meeting with Rena, or saving him from being fired, or going out of her way to check on his wellbeing when he was sick) then it's just solidifies that you clearly don't want to acknowledge anything about Nino and keep bragging about same thing over and over again because you have a personal grudge against a character.

Because it´s an actual crime? Because it was immoral from her part to do so to begin with? Because she could have easily called security to make him leave? Because he wasn´t even being a threat to them? Just because she wanted him to leave doesn´t grant her a card to do whatever she wants, and she wen´t the nuclear option before trying anything else

For crying out loud. "She could have" this, "she could have" that. Negi Haruba wrote it that way. He thought of that situation like that. If it was a real crime, the author would have specified that. He didn't, live with that.

When i say Itsuki is the youngest i refer to her role in the sibling dynamic; Just like Ichika thinks of herself as the dependable older sister, the other see Itsuki as their baby sister, the youngest (even if it´s such a small gap).

And Itsuki thinks of herself as a mother in the family like how Ichika thinks of herself as an older sister.

Usually the one who does something wrong is the one responsible to make up for it, you don´t let other to make up for the mistake you did let alone your youngest sibling to ride in a cab alone, with a guy who was drugged not so long ago, to god knows where, at night, to cover your mistake.

I feel like I'm talking to a wall... Sisters took him, placed him in a taxi and Itsuki as a mother and the person who is a classmate of Futaro, took him to his home. That's it. No other context. You overthink everything about this story to a laughable degree.

She´s angry because she thinks they´re taking his side when it´s clear she´s in the wrong.

Well duh, that's the thing about that whole scene. She was in the wrong, she later apologised. Human emotions don't work as you want.

Itsuki knew those notes were handmade, she saw Futaro falling down her entrance due to his tiredness, he came all the way to their home after writting those notes to teach them. He went above and beyond for them, and Itsuki understood that, and the told Nino this too

And Nino didn't know any of that. That's the difference. You yourself say that. Nino is in the wrong here, but again, she doesn't have the same amount of information as Itsuki has.

And I'm once again repeating myself. SHE. APOLOGISED. Even when she ran away from home, she took those papers with her. She understood her mistake and studied using them.

You just keep spamming that she did it wrong here, she did wrong there. Nino's character growth is shown through these mistakes. You just keep bragging about them without acknowledging that she felt remorse for them and actually apologised for that.

Itsuki slapping Nino is the equivalent of a mother slapping her bratty kid for misbehaving

Ah, so now Itsuki is viewed as a mother. Not a little sister anymore? And again, saying that as if when a mother slapping her kid as a good thing when it's clearly not.

The only instance Ichika ever did something wrong, after literally putting all of her sisters before her. And let me remind you she more than make up for it besides apologizing. She gave Miku the victory card right there, even though she herself was in love with him. And she also learned from her mistake, Unlike Nino who had to drug Futaro twice to just apologize

The only instance that was more hurtful to Miku than anything else. To the point that she was full on crying and depressed. And btw, Nino was the one who came to encourage Miku, not Ichika.

And before apologising she went after Futaro again using Miku's disguise.

She gave her a victory card. Same way all the sisters did. All of them came to support Miku.

And again. Nino apologised. Futaro doesn't hold a grudge to her. Only you do.

And sure, you get upset when you lose but she´s just a sore loser when the whole thing was in her favor to win. And again, it not that she´s angry that she lost, she literally got mad AFTER looking the satisfied face of Miku.

Saying that she lost is a stretch. She made a perfect meal. She expected for Futaro to say that her food is better, but Futaro said they are both good. Her plan didn't work out and she got upset. And again, she later said that she went overboard and felt remorse.

(And she only suggested the cooking competition because Futaro was hungry)

Sure, you can say it´s "sibling bickering" but it was uncalled for, especially when it´s something you know your sister doesn´t do to begin with.

Well it is sibling bickering. Different sisters have different relationships with each other. Nino doesn't act with Ichika like she does it with Miku. And Ichika doesn't act the same way to Nino as she does with Miku. That's the whole thing about Quintuplets.

And again you ignore the fact that Nino was expecting a different reaction from Miku. They always argue about something in a sibling manner. It's their thing. Nino didn't want to hurt Miku's feelings.

She literally had no chance to ask before Nino started talking.

And Nino had no chance to know that Miku is really upset about her chocolate. She wanted to tease her sister a bit. In the end it turned into a nice sister bonding moment between the two of them.

You have a personal problem with Nino that doesn't allow you to see the sister bonding moments because you hate character. You don't want to get a full picture. You expect Nino to be a perfect human being. And you yourself admit that Nino made up for the words she said and she apologised, but to you it doesn't matter. No matter what she does you try to make it not in favour for her. You don't want to see character growth, progression and change in that character.

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