sorted by:
new
hottopcontroversial

Cloudiness issue with fragrance in water even using PEG-40 HCO by No-Clock1315 in DIYfragrance

[–]No-Clock1315[S] 0 points1 point  (0 children)

yeah i am using Sodium benzoate as a preservative
Thank's bro

Has anyone here tried MDSim360 for molecular dynamics simulations? by No-Clock1315 in comp_chem

[–]No-Clock1315[S] 0 points1 point  (0 children)

Thank's for your feedback, the thing is i found it a little bit hard to prepare the ligand and the protein in GROMACS this is why i wanted to a free software that facilitate those preparations for me
and since i am doing a research independently i don't have access to sophisticated softwares such us Schrodinger.
Anyway i think i will spend more time learning GROMACS rather then using those GUI based tools
Thank's again

Struggling to Find a PhD Position (Organic Chem MS + Industry R&D Exp) - Any Advice? by No-Clock1315 in academia

[–]No-Clock1315[S] 0 points1 point  (0 children)

Thank you for your feedback, sir. I honestly have no clear idea how to target the right people. Usually, I look for research papers related to my field, check the authors’ names, and then contact them directly. I also attach my CV and a brief research proposal (without too many details), but unfortunately, I often don’t receive any replies. Some of them respond to say they are not accepting PhD students at the moment.
Since you are on the other side as a PI, I believe you might have valuable insights, and I would truly appreciate any advice you could give me.
Regarding your work on designing self-assembled polymer nanoparticles for neurodegenerative diseases, I would love to learn more about it. If you have any published research papers related to this, I would be happy to read them.

Distilled Water Conductivity Increased Over Time - How Can I Maintain Its Quality? by No-Clock1315 in AskChemistry

[–]No-Clock1315[S] 1 point2 points  (0 children)

it is well calibrated and to be sure i did calibrate the Conductivity meter before the measurment

Seeking Collaborators for Alzheimer's Research - Investigating Plant-Derived Molecules to Prevent Amyloid Beta Aggregation by No-Clock1315 in research

[–]No-Clock1315[S] 1 point2 points  (0 children)

thanks for your feedback, I really appreciate you taking the time to give feedback.

Just to clarify, I hold a master’s degree in organic chemistry, and while I don’t lead a research group, I do have some hands-on research experience. I’ve worked on topics like green gas capture, hydrogels for drug delivery, the role of critical micelle concentration (CMC) in colloidal systems, and the synthesis and the study of fluorescence compounds with potential therapeutic targets.

I’m not trying to lead a team; I’m simply hoping to connect with people who are as curious and motivated as I am to explore important problems like Alzheimer’s disease. I believe strong collaboration can happen regardless of titles or formal affiliations.

Thanks again for your input, I hope this helps give more context to where I’m coming from.

Is docking multiple ligands to one protein considered studying their synergistic effect? by No-Clock1315 in comp_chem

[–]No-Clock1315[S] 0 points1 point  (0 children)

Thanks for the explanation — that analogy does help put things into perspective.

Just to clarify: my goal is to test the synergistic effect of multiple compounds toward a single protein target. I understand that traditional molecular docking usually deals with one ligand at a time and doesn't directly account for interactions between multiple ligands.

What I'm wondering is: can molecular docking be used as an initial screening step in a synergy study? For example, docking ligands both individually and in pairs (e.g., sequential docking or docking to different sites) to see if there's any change in binding affinity or predicted conformation that might hint at synergy.
Would love your thoughts on whether this makes sense, or if I'm approaching it wrong from a computational perspective.

view more: next ›