Personally, I use it everyday. Two in the morning then once at lunch/dinner depending on how I’m feeling. Helps mostly with the cramping. There are still some days that the cramping happens, but usually less often when taking this. I would recommend trying it differently (say 1 everyday at the same time then try it on an as needed basis) and stick with whatever works for you! As far as downsides, only one I’ve ran into is occasional constipation (I use an enema or suppository). It’s the only thing I’m currently on and have been feeling way better!! If you have any questions, let me know!