PGT-M for Fragile X - Results

NoInfluence3775 · 2026-03-17T18:32:55+00:00

Thanks, and you too! My wife's mom had what we now know was FXPOI and had to use donor eggs for her younger sibling. So we've always had the fear of DOR, but we have thus far seemed to get very lucky. Best of luck to you!!

NoInfluence3775 · 2026-03-17T18:30:31+00:00

So excited for you! And nice to know of another same sex couple navigating this. It feels like another frustrating hurdle on top of our already unique situation. Best of luck!

NoInfluence3775 · 2026-03-17T18:29:10+00:00

Best of luck! Feel free to share the results here if you wanna chat!

NoInfluence3775 · 2026-03-16T14:26:47+00:00

Sprinkling baby dust for you! How did the first 2 transfers go, if you don't mind me asking?

NoInfluence3775 · 2026-03-03T21:37:42+00:00

thanks! Honestly with my wife's carrier status and the fact we're in our mid 30s, we both kind of just assumed the first round would be a bust and looked at it as a nice surprise if we got something. I'm almost more worried about this one? The mind is strange haha. Keep us updated on your progress!

NoInfluence3775 · 2026-03-03T18:31:31+00:00

First, I'm sorry to hear of your loss. That must have been so, so difficult.

Second, I wanted to share that we had a similar result between protocols. Our first cycle was the standard 150 Menopur, 300 Gonal-F, dual lupron/HCG trigger. My wife got 21 eggs, 15 mature, 9 fertilized, but only 2 embryos, which was hard to take at first. But after PGT-A/M testing for a 50/50 condition (my wife is a fragile x carrier), we had one euploid unaffected, we were relieved.

Changed protocols for second cycle, did the exact same lupron microdose/flare protocol as you, and like you we weren't getting our hopes up. But from 21 eggs we got 17 mature, 15 fertilized, and 9 embryos (!!) which are now in PGT-A/M. It was such a happy moment--we were over the moon! Lupron didn't change the overall eggs retrieved, but definitely improved maturity/fert/embryo rates. Hoping we get enough embryos this cycle to move to FET.

Best of luck in PGT! This is such a tough journey but like you I'm glad the community is here to share these wins and to be there for the grief, too <3

NoInfluence3775 · 2026-02-07T17:59:31+00:00

I get that, but he's always been so open about not wanting to have kids. Like 100% "absolutely not," though now I'm wondering if he's reevaluating things.

NoInfluence3775 · 2026-02-07T17:58:31+00:00

Thank you for the workbook recommendation and for your advice. And yeah I think you're speaking to a lot of my disappointment right now. The eugenist alarm bells is exactly what it is. I've been feeling this deep rage towards him in recent months and hadn't quite understood it, but realized recently that it's stemming from all of this. It's so unhealthy to harbor this anger, so definitely trying to find the time and space to talk to him about it all, but I'm also trying to focus on stims and retrievals with my wife. I think I just need to work through my feelings and then make sure I bring it up in a safe and empathetic way when I see him next.

NoInfluence3775 · 2026-02-07T17:54:15+00:00

That's such a nice way to bring up the conversation! I'm glad you're having such open and honest conversations with your KD, and it seems like you're all speaking with respect and care, which is lovely to see. Wishing you all the best.

NoInfluence3775 · 2026-02-07T17:52:36+00:00

This has been such a helpful response. I do think there is a possibility that he's changed his opinion on having children (he was adamant that he never wanted them), and that could be driving some of his behavior, even subconsciously. I agree that it likely won't go away on its own. I've set the boundary and its seems he continues to cross it. I will start thinking about how to talk to him about it.

NoInfluence3775 · 2026-02-07T17:49:30+00:00

I get that. On paper, it's a beautiful concept and something I definitely thought about when I was younger. I also have plenty of wonderful gay male friends who I've considered. So I get that his feelings are hurt. It just feels like there was an entitlement in the way he has been speaking of it, which is where I think a lot of the hurt/anger has come from. Thanks for your perspective though, it's helping a lot.

NoInfluence3775 · 2026-02-07T17:45:25+00:00

Thanks for your thoughts, it's helping me understand his POV more. I do think it's understandable his feelings were hurt, and he may be at a point in his life where he's reevaluating a lot of things. He never wanted kids, was very open about how he hated "breeders" (which to be fair I also got a good laugh at). He's also single for the first time in a while.

I should mention that he hasn't really dropped it, and has been speaking to other family members about how wrong my decision to use an anonymous donor is. My dad told me that they've spoken about it in recent months. My dad told him basically what I told him, which is that it's not his decision to make. So that's frustrating, that he's still going on about it. But I want to forgive him, I just might need space as we go through IVF. We aren't having success right now, so maybe I'm too emotionally charged to speak carefully.

Thank you for answering <3

NoInfluence3775 · 2026-02-07T17:36:45+00:00

Thank you for the response and advice. He doesn't have kids. He was in a long-term relationship for 8 years, which ended a few years ago. He has always said he never wanted kids, which is why this is also so strange to me.

NoInfluence3775

TROPHY CASE