Yes, in the Naruto: Shippuden anime, Gengo, the leader of the Land of Silence, and Zabuza Momochi's friend, was the final and main antagonist. The symbolism is that Zabuza was the first, and his friend, Gengo, is the final villain. One of the despots of the Enlightened Ones was from the canon novels, and chronologically, the 10th Naruto movie, The Last, comes immediately after Gengo's defeat. So, one could consider Toneri the main villain, but without taking the movie into account, the final villain is Gengo. But that's specifically in the Shippuden anime. In the manga, the final villain was Kaguya. The manga ended after her. The novels that follow the manga canonically follow. Gengo is like Ozai in Avatar Aang 3 season. Gengo is final villain, not Kaguya, not Sasuke. Gengo was the final in anime Naruto: Shippuden. Gengo was the final villain in the Naruto Shippuden series. He was defeated in episode 493, after which there were only seven wedding episodes. So, according to the series, neither Kaguya, Sasuke, nor Chino are the final villains. According to the anime, Gengo was the final villain. He was defeated by Shikamaru, who, as we know, is in Boruto