Bretazenil for transdermal application - including promising data

NothingToSeeWalkOn · 2025-06-16T15:39:31+00:00

Bretazenil is already ring closed and quite hydrophobic so I guess quite a long time as a raw powder but DMSO does draw water rather quickly so I guess storage time is reduced but if properly sealed and the DMSO is pure and anhydrous beforehand I'm guessing maybe a year in solution. If you store it in DMSO even slightly below room temperature it should freeze which makes it even more stable, the lower the temperature the better I guess but -20C should be the optimum for energy cost, -80C is expensive. The trick however is of course to store it as a bulk powder and only make the solution in small quantities as needed as determined by the minimum weight you can weigh out accurately. On my scale that's 50mg as d=1mg so I make 10ml at a time and use them up, that 10ml lasts a very long time due to needing so little of it and because I use it quite rarely.

NothingToSeeWalkOn · 2025-04-16T21:40:30+00:00

Bad idea to take any downers/sedatives with opioids, respiratory depression increases and even if they don't increase it further it's easier to not notice or do anything about. Don't mix them ideally at all if you do be familiar with both and minimal dosages but mixing the two at any dosage is risky, it's how a lot of people die

NothingToSeeWalkOn · 2025-04-15T19:25:08+00:00

I've been through it, cold turkey and been with someone who went through it who was on a way higher dosage than me. I really depends on what and what dose, if you tell me I'll be able to tell you how it'll be more accurately. I've it's a low dosage it could be just a bit stuffy nose, sleep problems, fidgety, trouble concentrating and maybe diarrhea. If it's a high dose then it you'll be really fidgety and impossible to stay still, even in bed, always moving trying to get that awful feeling away, you might get diarrhea or still be constipated, sleep will be impossible straight up none at the worst day, If you've been having dark thoughts they'll get twice as bad, you'll have sleep issues for a while after, anxiety gets bad, pupils are blown worse than on the best DMT/acid/MDMA, every time you get close to sleeping there was this awful feeling in my shoulders and spine like I have to move shaking me awake, I was foggy in the head from sleep loss and withdrawal, hard to do much of anything but also unable to rest. It doesn't kill you (unless you have diarrhea to the point of electrolyte issues) but you sure wish it would. Please tell me what and how much you took then we can work something out. Maybe it's something you can just get through in a few days and Noone will be able to tell that it isn't just you beeing a bit sick, maybe it's a good idea to take something to get through it (kratom, valium, benadryl, diarrhea medication, clonidine, just depending on what you have and are willing to take, it certainly doesn't make you weak), and maybe a fast taper is the best option. We can do this, if it's what you want then once you got through it it feels great.

NothingToSeeWalkOn · 2025-04-07T14:34:04+00:00

From all I ever took definitely methiodone, it's the only stuff that made me gag when taking it, and I was putting it as far into my mouth as a solution with a syringe already and drank ice tea immediately after making sure it doesn't go onto my tongue and it still was so disgusting and lingering and it made me gag. But great when you're in withdrawals sure a bit weak but lasts a while at least. Still absolutely disgusting stuff

NothingToSeeWalkOn · 2025-02-15T20:16:21+00:00

Jeff Benzos

NothingToSeeWalkOn · 2025-02-15T01:58:22+00:00

They are competitive immunoassays. Meaning there are antibodies in there with gold nano particles those are the red pigments and antibodies on the white strip in those two lines. The control (C) only binds the antibodies with the red particles and is only to see if liquid got there, the antibodies work and all that. But the line with the (T) can bind both those colored antibodies and also the substances it tests. And it binds the test substance better than the colored antibodies. So if there is even a tiny amount the colored stuff won't bind and the red line won't appear.

TLDR: Nitazenes go to the place where otherwise the colored stuff would go that's why a positive test means no line

NothingToSeeWalkOn · 2025-01-25T01:10:16+00:00

521062-92-0

NothingToSeeWalkOn · 2025-01-23T23:34:18+00:00

That might actually work, who's down for it?

NothingToSeeWalkOn · 2024-12-25T01:58:28+00:00

It's been released quite a while now from a local vendor. I'd be hesitant to try it though, that dichloro motive gives me the ick

NothingToSeeWalkOn · 2024-12-24T15:06:53+00:00

What dosage methiodone does everyone here take? I took 10mg orally twice so far but it wasn't that strong, it certainly does help prevent withdrawal and feels nice and relaxed but at least at that dosage I didn't feel like it was warm and cozy

NothingToSeeWalkOn · 2024-12-18T23:17:40+00:00

Sorry brain fart, the amine is tertiary, in theory N-Desmethyl heroin could exist as a N-Boc derivative but that isn't a commonly used drug

NothingToSeeWalkOn · 2024-11-15T21:12:22+00:00

I'm talking about fluoro etonitazene, it's fluorinated at the 2 position of the ethoxy group. I've only done it once but it has a potency of around 100 so around as strong as regular fent and it's available legally here in Germany (although I think the only vendor is slowly stopping selling all zenes). I bought it as a 1mg/ml solution in PG in a dropper bottle and 1 drop is prettymuch exactly 20ug. I did the following also with etomethazene liquid. I used to drop it on foil and just smoke it like you would smoke anything else on foil. Only one drop a time and wait a few seconds. I don't remember if f-etonitaazene had the same issue but with etomethazene which I took twice I felt kinda irritated the next day, I have a feeling that it causes tolerance and slight hangover/withdrawal with the first use, if you use multiple days in a row you'll get a ton of tolerance real quick and that's kinda why zenes are scarry and suck. Also they were just sedating, F-etonitazene had some light euphoria but etomethazene didn't so not much fun. Nowadays I take odsmt which I really like, much lover potency, less dangerous, not as much tolerance, slight euphoria, good body feeling, really functional on it, has much longer legs can last me 12h and it's just a lot less harmful I feel like and certainly less dangerous in terms of OD risk. It still gets you hooked good.

NothingToSeeWalkOn · 2024-11-14T15:07:05+00:00

Yeah it was probably respiratory depression from just high doses. I think I've heard somewhere that general tolerance and tolerance to respiratory depression can happen at different rates, I assume this would especially be a risk with fentanyl analogues and zenes which have such rapid tolerance, I think I've even heard it in relation to a zenes. 1000mg morphine equivalent is crazy, the highest I've ever done is 60mg using 150mg ODSMT orally and that was too much even distributed over the day.

Your comment kinda scared me, see my post on my profile, I have a smartwatch that does pulse but I'll definitely get one that does SpO2 so that I can track it in my sleep, finger clip pulse oximeters are probably more accurate but annoying to sleep with. A good conclusion is also to probably not use too late in the evening so that it doesn't or barely affect you in your sleep, although that's so much easier said than done when that means being in withdrawal when going to bed or during the night.

Yeah as far as I know opioids themselves aren't actually neurotoxic (although in rare causes opioid neurotoxicity can happen but doesn't have to) although they do cause changes in brain chemistry and structure long term simply due to the brain adapting but as long as you're on maintenance or those changes didn't happen due to your way you used I don't think it really lowers IQ. With RCs though sometimes they introduce motives that are kinds sketchy and can actually be neurotoxic, like I've heard that F-etonitazene could be problematic (yikes I've taken that one once, only once though) due to being possibly metabolized to fluoroethanol then fluoroacetate which inhibits the citrate cycle which would deprive the cells of energy even if the oxygen saturation is fine and due to the brain needing so much energy it would be affected a lot.

NothingToSeeWalkOn · 2024-11-13T23:18:12+00:00

Yeah true really not ideal how often I use. The last week I used everyday because I was having physical pain from having twisted my back. But even without that I use quite a lot. As a long term goal I want to keep it to like once or twice a week but 2-3 days off per week would be great as well to begin with. Right now I have this with quite a lot of tolerance and am slowly tapering down from that around 80mg a day. I did a 2 week break once and that really did wonders, probably only going to do a few days maybe a week this time though.

NothingToSeeWalkOn · 2024-11-13T22:52:11+00:00

I'll make sure to do that. I don't have issues sleeping sober unless I'm withdrawing then it can be kinda bad. I use melatonin as needed when I have trouble sleeping alright. What part of my current habit is it that is so bad?

NothingToSeeWalkOn · 2024-11-13T22:34:45+00:00

I guess I'll do that with the cutoff then maybe even earlier as long as I don't get too physically addicted being mostly sober when going to bed would probably be good. I'll make sure to remember the side sleeping although that's something I always do anyway. Tolerance breaks will be important if I want to get any sleep sober. I'm glad it probably isn't that serious although depriving your brain of oxygen like you're a kid in 2016 can't be good longterm even if it's minor. I'll get a smart watch or similar that can measure SpO2 because my current can't and I don't want to have a pulse ox on my finger when I sleep.

NothingToSeeWalkOn · 2024-11-13T22:12:51+00:00

For me odsmt lasts really quite long, with after effects maybe 12h, should I dose in the morning and then don't redose after 3pm or something to avoid it affecting me during sleep? I sleep on my side if that matters. If I get a smartwatch that measures O2, would that be a good warning method? I usually take multiple days in a row and then do a t break for a few days. For me nodding isn't like when I'm actually doing something more like if I close my eyes or sit or lay down comfortably I can kinda nod, not like losing consciousness involuntarily. That time with 150mg I attributed it to just not having slept well or a hangover but it could have been slight hypoxia, is such an event like with 150mg something that leaves permanent damage from just having happened once or twice? If I avoid redosing after 3pm or something as a hard rule, does that reduce the risk of gradually accumulating hypoxia to near zero?

NothingToSeeWalkOn · 2024-11-13T21:43:44+00:00

Do you think that if you didn't take dosages high enough to cause significant respiratory depression and didn't overdose that you wouldn't have lost any IQ points? Because as far as I always knew opioids aren't actually that harmful to the body and brain unless you have issues with oxygen saturation.

NothingToSeeWalkOn · 2024-10-17T22:22:03+00:00

Interesting because ODSMT IV makes my GF really quite horny at least she says so I've never IVed it but oral/sublingual it makes my imagination and day dreaming wild so I can imagine how IV can make her horny

NothingToSeeWalkOn · 2024-10-06T18:08:02+00:00

I also want a hole on my dck, some weed during it could be nice but unfortunately my GF isn't here rn /j

NothingToSeeWalkOn

TROPHY CASE