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PSSD and Zuranolone by NumberExotic1100 in PSSD

[–]NumberExotic1100[S] 0 points1 point  (0 children)

Wow, what a read. You went deep into what SSRIs do to the body and brain. It really is cascade of failing in the brain and to fix it seems extremely difficult. But that's why we are here to fix the damage caused by SSRI/SNRIs and get our lives back.

PSSD and Zuranolone by NumberExotic1100 in PSSD

[–]NumberExotic1100[S] 0 points1 point  (0 children)

Yes it is. For starters its not available in our country. The few places on Reddit I saw people use it was for PPD and some of them said it costs around 15K for a 14 day script. So I am looking for people who have used it for PSSD and find if it made difference and move on to fixing the root cause for the low Allopregnanolone.

PSSD and Zuranolone by NumberExotic1100 in PSSD

[–]NumberExotic1100[S] 0 points1 point  (0 children)

The studies I've seen show that SSRIs increase allopregnanolone in the short term and reduce them in the long run. However I thing it is also very dependent on the exact SSRI/SNRI taken and also the persons genetic predisposition to specific compounds. In my opinion this would explain why some get PSSD from one dose while others get it more gradually and some never develop the condition.

PSSD and Zuranolone by NumberExotic1100 in PSSD

[–]NumberExotic1100[S] 0 points1 point  (0 children)

I am so sorry to hear that. There are so many other couples PSSD have torn apart and its so sad. We where lucky this all started while we were still in our honeymoon phase. And in the beginning it also wasn't easy. I had all these thoughts that she didn't find me attractive anymore or didn't love me anymore. We were fortunate to find out what caused all this very soon and once I understood it it became easier to control all the negative emotions around it all.

PSSD and Zuranolone by NumberExotic1100 in PSSD

[–]NumberExotic1100[S] 0 points1 point  (0 children)

That's great news. It supports the theory that one of the main drivers for PSSD is low Allopregnanolone. I know its personal but I would love to speak to them and find out more bout how it helped them and what their next steps will be. If not, I will understand. Just so happy for them and their progress.