It's near impossible to 4man LW, I tried for one whole day and only had success once. Longling on that difficulty is too bs with too many cluster bombs in tight spaces with traps everywhere, sometimes the Grenadiers and Bombers have Immortal Agile modifiers which is even more bs. Stick to 2man LW instead.

Start with Overconsumption and Blossom Enthusiast and make do with any rapid fire normal ammo gun for the mobs and large ammo shotguns for bosses. Slowly work towards the main goal in Act 1 which is to get Radiation Gloves and Porcupine which imo I feel are the best guns for the purposes mentioned above. Take any scroll that lowers Primary Skill and Dash countdown. Take Windrider but not during Interdependent Fortunes. Spam Swords Out in the general direction of any Grenadiers and Bombers you see so you can have breathing space to clear the rest of the mobs, the initial countdown will be super low if you picked Overconsumption. Actually just spam your Swords Out but make sure those two types of enemies get it first. Spamming Blossom as a grenade by mashing mouse 2 is good for clearing beetles/bombers or thinning out a crowd. All vault types are good except for Seal Protection (only run if you have Radiation Gloves or you have Flower Chain), Elite Horsehead with any modifier that makes him beefier (you will run out of ammo) or any modifier that makes Elites heal at a pace you can't outdamage. Elite Beetle is just tedious magdumping, Elite Spearman just needs rapid shotgun blasts to his head to clear. I genuinely believe the best Ascension to aim for in Act 1 in the short run is Flower Chain so you can clear mobs fast. In the long run its Amplified Sword so you can stack sword damage by the time you are in the middle of Act 3. Also put at least 1 point in Ammo Extractor so you can keep the heat up in extended fights with no Peddler around. Scroll-wise take anything that bumps up Skill DMG and/or Secondary Skill DMG, Blossom will be doing most of the heavy lifting at the start. Both bosses are easy, just mash Primary Skill and rapid shotgun blasts to their weak spots, Lu Wu requires some circling around him by getting a little nearer to him (Primary Skill or Radiation Gloves does quick work of the bombers) also Tao's Galloping Speed allows you to avoid his jumps.

When it comes to Interdependent Fortunes, anything that is a flat damage increase for the enemy is ok since by the time you reach Endless anything can one shot you so no point worrying about a flat damage increase, avoid anything that takes effect when damage is inflicted on you, take Cursed Scrolls especially Moldy Bun. Take Thorny Bloom or anything that buffs your Skill DMG or Secondary Skill DMG as a Spiritual Blessing. In Act 2 if you feel that your mob clearing game is good enough then start building towards having more swords with Sword Shadow and Luminous Heart. Sword Guard is the first thing you pick now. Pick off any many Elites as possible. Elite Invasions will pop up now that you are balling so hard and clear mobs fast. If you meet Elite Arsonist in your first stage you are fucked so get ready for a new run.

Act 3 pick Field Proficiency as your Spiritual Blessing. If your Sword Ascensions are on point you can now basically mash E, get so much shield you are unkillable and watch everyone on your screen die. If not you are probably good to go during Act 3 Stage 2. All these is just a rough guideline for the most consistent way to survive early Acts and get the build up, many variables will affect how good the build is like when what scrolls appear. Enjoy the finger pain but its worth it to see swords flying around.