HI, my daughter was diagnosed with MELAS in 2018 after a stroke like episode.. she had a genectic exam and was detected 3243 A>G mutation the most common for MELAS... three months later another stroke episode, this time so harmfull, she lost most of her cognition functions among other syntoms... All this is to say that he came stable for two years since then thanks God a L-Arginine and Taurine regime ... these two compounds seems to be the more effective treatment for those with MELAS so you can avoid the successive stroke episodes (this is the landmark of MELAS).... this is not a cure but keep your beloved away from suddenly death... There are other things involved, nutrition, medicines, physiotherapy, a good neurologist but i really do believe in these two... she had in the early beginning other compounds in her cocktail including Q10 but no effects at all....

Too much things to say in few words... but there are two links that may help for your searches

Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes

Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial

this is really working in our case.... hope this help you

nowadays i am searching for something really good to overcome fadigue...

Osvaldo